Tc-99m HMPAO leukocyte and Tc-99m nanocolloid scintigraphy in posttraumatic bone infection

Miklós Papós, Ferenc Barát, György Nárai, József Dillmann, Jenö Láng, László Csernay

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Posttraumatic osteomyelitis was investigated in 23 patients using nuclear medicine techniques. Tc-99m hexamethylpropilene amine oxime (HMPAO)- labeled leukocyte scintigraphy was performed in 11 patients, and Tc-99m, nanocolloid scanning was performed in the other 12 patients. The scintigraphic findings were compared with clinical, laboratory, radiologic, and bacteriologic results. The findings on leukocyte imaging were consistent with the clinical symptoms in 7 of 11 patients, with the laboratory pattern in 7 of 10 patients, with the radiologic findings in 7 of 11 patients, and with the results of bacteriology in 6 of 7 patients. The findings on nanocolloid scintigraphy corresponded with the clinical symptoms in 9 of 12 patients, with the laboratory pattern in 8 of 10 patients, with the radiologic findings in 8 of 12 patients, and with the bacteriology in 4 of 5 patients. The results suggest that both methods were of similar value for the detection of chronic posttraumatic osteomyelitis regardless of whether the process was active. Conversely, on the basis of semiquantitative analysis of the images, leukocyte scintigraphy seemed to characterize the grade of inflammation better than did nanocolloid scintigraphy.

Original languageEnglish
Pages (from-to)423-428
Number of pages6
JournalClinical nuclear medicine
Issue number7
Publication statusPublished - Jul 1 1998



  • Leukocyte Scintigraphy
  • Nanocolloid Scintigraphy
  • Posttraumatic Osteomyelitis
  • Semiquantitative analysis of Images

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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