Taurine modulates glycine response in Xenopus oocytes injected with messenger RNA from mouse brain

Tetsuro Horikoshi, Atsushi Asanuma, Keiji Yanagisawa, Sataro Goto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The modulatory action of taurine on the glycine response was investigated in Xenopus oocytes injected with messenger RNA from mouse brainstem under voltage-clamped condition. Taurine competitively inhibited the glycine response in a dose-dependent manner. This inhibition was insensitive to bicuculline and intracellularly injected EGTA. The results suggest that taurine could directly modulate glycinergic neurotransmission in the central nervous system.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalMolecular Brain Research
Volume4
Issue number3
DOIs
Publication statusPublished - Nov 1988

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Keywords

  • Glycine
  • Mouse brain
  • Neuromodulator
  • Taurine
  • Xenopus oocyte
  • mRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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