Taurine Levels in Discrete Brain Nuclei of Rats

Miklós Palkovits, István Elekes, Tibor Láng, András Patthy

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Abstract Concentrations of taurine have been measured in 44 microdissected rat brain nuclei or areas. Taurine is ubiquitously present and distributed unevenly in the rat brain: the ratio of the highest (pyriform cortex) to lowest (midbrain reticular formation) concentrations is 4.7:1. High taurine levels were found in cerebral cortical areas, caudate‐puta‐men, cerebellum, median eminence, and supraoptic nucleus. Acute pain stress reduced taurine levels in the hypothalamus and the lower brainstem nuclei but not in cortical areas. Increased locomotor and behavioral activities following a high dose of amphetamine elevated taurine concentrations significantly in the substantia nigra and locus ceruleus.

Original languageEnglish
Pages (from-to)1333-1335
Number of pages3
JournalJournal of neurochemistry
Volume47
Issue number5
DOIs
Publication statusPublished - Nov 1986

    Fingerprint

Keywords

  • Amphetamine
  • Pain stress
  • Rat brain nuclei
  • Taurine

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this