Tau haplotypes and ApoE4 do not act in synergy on Alzheimer's disease

Péter Z. Álmos, Szatmár Horváth, Ágnes Czibula, István Raskó, Nóra Domján, Anna Juhász, Zoltán Janka, János Kálmán

Research output: Contribution to journalArticle

Abstract

There are conflicting results regarding the role of tau (MAPT) haplotypes in neurodegenerative disorders. Recent reports suggest that ethnicity factors and gene-gene interactions may influence the risk of developing Alzheimer's disease (AD). The present study investigates possible synergism between MAPT haplotype and ApoE state in Hungarian Caucasian AD cases (n = 91) and control (n = 83) population. The difference in MAPT H1 allele frequency did not reach significant level in AD (78%), and control individuals (73.5%), however ApoE4 carriers were significantly overrepresented in AD (34.1% vs. 20%) compared to the control population. Though a specific combination of ApoE4 and H1 alleles were found to be associated to AD (14.5% vs. 30.8%), synergistic genetic interaction could not be inferred. Our findings support the notion that while ApoE4 might be involved in AD pathology the MAPT H1 allele neither associates nor interacts through an epistasis with ApoE4 in the development of the disease.

Original languageEnglish
Pages (from-to)448-450
Number of pages3
JournalPsychiatry research
Volume186
Issue number2-3
DOIs
Publication statusPublished - Apr 30 2011

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Keywords

  • Epistasis
  • MAPT
  • Tauopathies

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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