TASK-1 (KCNK3) channels in the lung: From cell biology to clinical implications

Andrea Olschewski, Emma L. Veale, Bence M. Nagy, Chandran Nagaraj, Grazyna Kwapiszewska, Fabrice Antigny, Mélanie Lambert, Marc Humbert, Gábor Czirják, Péter Enyedi, Alistair Mathie

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22 Citations (Scopus)

Abstract

TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. This gene subfamily is constitutively active at physiological resting membrane potentials in excitable cells, including smooth muscle cells, and has been particularly linked to the human pulmonary circulation. TASK-1 channels are sensitive to a wide array of physiological and pharmacological mediators that affect their activity such as unsaturated fatty acids, extracellular pH, hypoxia, anaesthetics and intracellular signalling pathways. Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. Furthermore, mutations in KCNK3 have been identified as a rare cause of both familial and idiopathic pulmonary arterial hypertension. This review summarises our current state of knowledge of the functional role of TASK-1 channels in the pulmonary circulation in health and disease, with special emphasis on current advancements in the field.

Original languageEnglish
Article number1700754
JournalEuropean Respiratory Journal
Volume50
Issue number5
DOIs
Publication statusPublished - Nov 1 2017

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ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Olschewski, A., Veale, E. L., Nagy, B. M., Nagaraj, C., Kwapiszewska, G., Antigny, F., Lambert, M., Humbert, M., Czirják, G., Enyedi, P., & Mathie, A. (2017). TASK-1 (KCNK3) channels in the lung: From cell biology to clinical implications. European Respiratory Journal, 50(5), [1700754]. https://doi.org/10.1183/13993003.00754-2017