Targeting mitochondrial ATP-sensitive potassium channels - A novel approach to neuroprotection

David W. Busija, Z. Lacza, Nishadi Rajapakse, Katsuyoshi Shimizu, Béla Kis, F. Bari, F. Domoki, Takashi Horiguchi

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Mitochondrial responses to ischemic stress play an important role in necrosis and apoptosis of brain cells. Recent studies using several different experimental preparations have shown that activation of ATP-sensitive potassium channels in mitochondria (mitoK ATP channels) is able to protect neurons and astroglia against injury and death. Thus, targeting of mitoK ATP channels appears to be a novel approach to neuroprotection. However, little is known about the mechanisms involved. The purpose of this review is to detail the current state of knowledge about this important, emerging area of investigation, and to provide suggestions for future studies.

Original languageEnglish
Pages (from-to)282-294
Number of pages13
JournalBrain Research Reviews
Volume46
Issue number3
DOIs
Publication statusPublished - Nov 2004

Fingerprint

KATP Channels
Astrocytes
Mitochondria
Necrosis
Apoptosis
Neurons
Wounds and Injuries
Brain
mitochondrial K(ATP) channel
Neuroprotection

Keywords

  • Apoptosis
  • Diazoxide
  • Inwardly rectifying potassium channel
  • Ischemia
  • Mitochondrion
  • Necrosis
  • Sulfonylurea receptors

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Targeting mitochondrial ATP-sensitive potassium channels - A novel approach to neuroprotection. / Busija, David W.; Lacza, Z.; Rajapakse, Nishadi; Shimizu, Katsuyoshi; Kis, Béla; Bari, F.; Domoki, F.; Horiguchi, Takashi.

In: Brain Research Reviews, Vol. 46, No. 3, 11.2004, p. 282-294.

Research output: Contribution to journalArticle

Busija, David W. ; Lacza, Z. ; Rajapakse, Nishadi ; Shimizu, Katsuyoshi ; Kis, Béla ; Bari, F. ; Domoki, F. ; Horiguchi, Takashi. / Targeting mitochondrial ATP-sensitive potassium channels - A novel approach to neuroprotection. In: Brain Research Reviews. 2004 ; Vol. 46, No. 3. pp. 282-294.
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