Target structure-based modeling of the glutamate transporter pharmacophore

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Comparison of binding interactions of a bacterial Glu transporter homologue and the extracellular binding domain of metabotropic Glu receptor subtype (mGlu1) showed Glu adopting bent and extended conformations in Glu transporter and mGlu1, respectively.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalLetters in Drug Design and Discovery
Volume3
Issue number5
DOIs
Publication statusPublished - Jul 10 2006

Keywords

  • Docking and molecular dynamics
  • GABA
  • Glutamate
  • Glutamate transporter
  • L-trans-2,4-PDC
  • Metabotropic Glu receptor subtype 1

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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