Target-selective GABAergic control of entorhinal cortex output

C. Varga, Soo Yeun Lee, Ivan Soltesz

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We found that cannabinoid type 1 receptor-expressing GABAergic basket cells selectively innervated principal cells in layer II of the rat MEC that projected outside the hippocampus but avoided neighboring cells that give rise to the perforant pathway to the dentate gyrus. These results indicate that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons.

Original languageEnglish
Pages (from-to)822-824
Number of pages3
JournalNature Neuroscience
Volume13
Issue number7
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Entorhinal Cortex
Perforant Pathway
Cannabinoid Receptors
Dentate Gyrus
Hippocampus
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Target-selective GABAergic control of entorhinal cortex output. / Varga, C.; Lee, Soo Yeun; Soltesz, Ivan.

In: Nature Neuroscience, Vol. 13, No. 7, 07.2010, p. 822-824.

Research output: Contribution to journalArticle

Varga, C. ; Lee, Soo Yeun ; Soltesz, Ivan. / Target-selective GABAergic control of entorhinal cortex output. In: Nature Neuroscience. 2010 ; Vol. 13, No. 7. pp. 822-824.
@article{816636aad7e343938d7af3ec773a1aa9,
title = "Target-selective GABAergic control of entorhinal cortex output",
abstract = "The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We found that cannabinoid type 1 receptor-expressing GABAergic basket cells selectively innervated principal cells in layer II of the rat MEC that projected outside the hippocampus but avoided neighboring cells that give rise to the perforant pathway to the dentate gyrus. These results indicate that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons.",
author = "C. Varga and Lee, {Soo Yeun} and Ivan Soltesz",
year = "2010",
month = "7",
doi = "10.1038/nn.2570",
language = "English",
volume = "13",
pages = "822--824",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Target-selective GABAergic control of entorhinal cortex output

AU - Varga, C.

AU - Lee, Soo Yeun

AU - Soltesz, Ivan

PY - 2010/7

Y1 - 2010/7

N2 - The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We found that cannabinoid type 1 receptor-expressing GABAergic basket cells selectively innervated principal cells in layer II of the rat MEC that projected outside the hippocampus but avoided neighboring cells that give rise to the perforant pathway to the dentate gyrus. These results indicate that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons.

AB - The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We found that cannabinoid type 1 receptor-expressing GABAergic basket cells selectively innervated principal cells in layer II of the rat MEC that projected outside the hippocampus but avoided neighboring cells that give rise to the perforant pathway to the dentate gyrus. These results indicate that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons.

UR - http://www.scopus.com/inward/record.url?scp=77954141740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954141740&partnerID=8YFLogxK

U2 - 10.1038/nn.2570

DO - 10.1038/nn.2570

M3 - Article

VL - 13

SP - 822

EP - 824

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 7

ER -