Target-organ damage in adolescent hypertension. Analysis of potential influencing factors, especially nitric oxide and endothelin-1

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Abstract

Background and purpose: To assess the role of the nitric oxide-endothelin imbalance in the development of target-organ damages (carotid intima-media thickness and left ventricular mass index) in adolescent hypertension. Methods: 125 adolescents - 67 hypertensive and 58 normotensive - underwent routine anthropology (height, weight) and blood pressure measurements, and laboratory (glucose, cholesterol and triglyceride levels) testing as well as sampling blood for determination of the plasma concentrations of nitric oxide (NOx) and endothelin-1 (ET-1), followed by measurement of the carotid intima-media thickness (IMT) and left ventricular mass index (LVMI). Results: Plasma concentration of NOx was significantly lower (27.7 ± 13.7 vs. 35.8 ± 7.0 μmol/l, respectively, p <0.001) and ET-1 was higher (3.11 ± 3.9 vs. 1.09 ± 1.07 fmol/ml, respectively, p <0.001) in hypertensive adolescents than that of controls. NOx negatively, endothelin positively correlated with blood pressure values, especially with systolic BP. An inverse relationship has been found between NOx and ET-1 concentrations (r = - 0.29, p <0.003). In this adolescent population body weight, systolic blood pressure and plasma ET-1 were the most important factors influencing IMT, whereas LVMI correlated with height and weight and systolic BP of the teenagers. Conclusions: NO/endothelin imbalance seems to play a role in the development of hypertension and target-organ damages in adolescence. Further studies are encouraged in order to clarify the pathophysiological role of NO/endothelin imbalance in adolescent hypertension.

Original languageEnglish
Pages (from-to)138-143
Number of pages6
JournalJournal of the Neurological Sciences
Volume247
Issue number2
DOIs
Publication statusPublished - Sep 25 2006

Fingerprint

Endothelin-1
Nitric Oxide
Hypertension
Endothelins
Blood Pressure
Carotid Intima-Media Thickness
Weights and Measures
Anthropology
Triglycerides
Cholesterol
Body Weight
Glucose
Population

Keywords

  • Adolescent hypertension
  • Carotid intima-media thickness
  • Endothelin
  • Left ventricular mass index
  • Nitric oxide

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

@article{54675b0148d24ce7afec23e96d766de7,
title = "Target-organ damage in adolescent hypertension. Analysis of potential influencing factors, especially nitric oxide and endothelin-1",
abstract = "Background and purpose: To assess the role of the nitric oxide-endothelin imbalance in the development of target-organ damages (carotid intima-media thickness and left ventricular mass index) in adolescent hypertension. Methods: 125 adolescents - 67 hypertensive and 58 normotensive - underwent routine anthropology (height, weight) and blood pressure measurements, and laboratory (glucose, cholesterol and triglyceride levels) testing as well as sampling blood for determination of the plasma concentrations of nitric oxide (NOx) and endothelin-1 (ET-1), followed by measurement of the carotid intima-media thickness (IMT) and left ventricular mass index (LVMI). Results: Plasma concentration of NOx was significantly lower (27.7 ± 13.7 vs. 35.8 ± 7.0 μmol/l, respectively, p <0.001) and ET-1 was higher (3.11 ± 3.9 vs. 1.09 ± 1.07 fmol/ml, respectively, p <0.001) in hypertensive adolescents than that of controls. NOx negatively, endothelin positively correlated with blood pressure values, especially with systolic BP. An inverse relationship has been found between NOx and ET-1 concentrations (r = - 0.29, p <0.003). In this adolescent population body weight, systolic blood pressure and plasma ET-1 were the most important factors influencing IMT, whereas LVMI correlated with height and weight and systolic BP of the teenagers. Conclusions: NO/endothelin imbalance seems to play a role in the development of hypertension and target-organ damages in adolescence. Further studies are encouraged in order to clarify the pathophysiological role of NO/endothelin imbalance in adolescent hypertension.",
keywords = "Adolescent hypertension, Carotid intima-media thickness, Endothelin, Left ventricular mass index, Nitric oxide",
author = "E. Katona and Georgios Settakis and Z. Varga and G. Paragh and D. Bereczki and B. F{\"u}lesdi and D. P{\'a}ll",
year = "2006",
month = "9",
day = "25",
doi = "10.1016/j.jns.2006.04.007",
language = "English",
volume = "247",
pages = "138--143",
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T1 - Target-organ damage in adolescent hypertension. Analysis of potential influencing factors, especially nitric oxide and endothelin-1

AU - Katona, E.

AU - Settakis, Georgios

AU - Varga, Z.

AU - Paragh, G.

AU - Bereczki, D.

AU - Fülesdi, B.

AU - Páll, D.

PY - 2006/9/25

Y1 - 2006/9/25

N2 - Background and purpose: To assess the role of the nitric oxide-endothelin imbalance in the development of target-organ damages (carotid intima-media thickness and left ventricular mass index) in adolescent hypertension. Methods: 125 adolescents - 67 hypertensive and 58 normotensive - underwent routine anthropology (height, weight) and blood pressure measurements, and laboratory (glucose, cholesterol and triglyceride levels) testing as well as sampling blood for determination of the plasma concentrations of nitric oxide (NOx) and endothelin-1 (ET-1), followed by measurement of the carotid intima-media thickness (IMT) and left ventricular mass index (LVMI). Results: Plasma concentration of NOx was significantly lower (27.7 ± 13.7 vs. 35.8 ± 7.0 μmol/l, respectively, p <0.001) and ET-1 was higher (3.11 ± 3.9 vs. 1.09 ± 1.07 fmol/ml, respectively, p <0.001) in hypertensive adolescents than that of controls. NOx negatively, endothelin positively correlated with blood pressure values, especially with systolic BP. An inverse relationship has been found between NOx and ET-1 concentrations (r = - 0.29, p <0.003). In this adolescent population body weight, systolic blood pressure and plasma ET-1 were the most important factors influencing IMT, whereas LVMI correlated with height and weight and systolic BP of the teenagers. Conclusions: NO/endothelin imbalance seems to play a role in the development of hypertension and target-organ damages in adolescence. Further studies are encouraged in order to clarify the pathophysiological role of NO/endothelin imbalance in adolescent hypertension.

AB - Background and purpose: To assess the role of the nitric oxide-endothelin imbalance in the development of target-organ damages (carotid intima-media thickness and left ventricular mass index) in adolescent hypertension. Methods: 125 adolescents - 67 hypertensive and 58 normotensive - underwent routine anthropology (height, weight) and blood pressure measurements, and laboratory (glucose, cholesterol and triglyceride levels) testing as well as sampling blood for determination of the plasma concentrations of nitric oxide (NOx) and endothelin-1 (ET-1), followed by measurement of the carotid intima-media thickness (IMT) and left ventricular mass index (LVMI). Results: Plasma concentration of NOx was significantly lower (27.7 ± 13.7 vs. 35.8 ± 7.0 μmol/l, respectively, p <0.001) and ET-1 was higher (3.11 ± 3.9 vs. 1.09 ± 1.07 fmol/ml, respectively, p <0.001) in hypertensive adolescents than that of controls. NOx negatively, endothelin positively correlated with blood pressure values, especially with systolic BP. An inverse relationship has been found between NOx and ET-1 concentrations (r = - 0.29, p <0.003). In this adolescent population body weight, systolic blood pressure and plasma ET-1 were the most important factors influencing IMT, whereas LVMI correlated with height and weight and systolic BP of the teenagers. Conclusions: NO/endothelin imbalance seems to play a role in the development of hypertension and target-organ damages in adolescence. Further studies are encouraged in order to clarify the pathophysiological role of NO/endothelin imbalance in adolescent hypertension.

KW - Adolescent hypertension

KW - Carotid intima-media thickness

KW - Endothelin

KW - Left ventricular mass index

KW - Nitric oxide

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U2 - 10.1016/j.jns.2006.04.007

DO - 10.1016/j.jns.2006.04.007

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JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

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