Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone

Ryuichi Shigemoto, Akos Kulik, J. David B Roberts, Hitoshi Ohishi, Z. Nusser, Takeshi Kaneko, Peter Somogyi

Research output: Contribution to journalArticle

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Abstract

The probability of synaptic neurotransmitter release from nerve terminals is regulated by presynaptic receptors responding to transmitters released from the same nerve terminal or from terminals of other neurons. The release of glutamate, the major excitatory neurotransmitter, is suppressed by presynaptic auto receptors. Here we show that a metabotropic glutamate receptor (mGluR7) in the rat hippocampus is restricted to the presynaptic grid, the site of synaptic vesicle fusion. Pyramidal cell terminals presynaptic to mGluR1α-expressing interneurons have at least a ten-fold higher level of presynaptic mGluR7 than terminals making synapses with pyramidal cells and other types of interneuron. Distinct levels of mGluR7 are found at different synapses made by individual pyramidal axons or even single boutons. These results raise the possibility that presynaptic neurons could regulate the probability of transmitter release at individual synapses according to the postsynaptic target.

Original languageEnglish
Pages (from-to)523-525
Number of pages3
JournalNature
Volume381
Issue number6582
DOIs
Publication statusPublished - 1996

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Metabotropic Glutamate Receptors
Synapses
Presynaptic Receptors
Pyramidal Cells
Presynaptic Terminals
Interneurons
Neurotransmitter Agents
Neurons
Synaptic Vesicles
Axons
Glutamic Acid
Hippocampus
metabotropic glutamate receptor 7

ASJC Scopus subject areas

  • General

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Shigemoto, R., Kulik, A., Roberts, J. D. B., Ohishi, H., Nusser, Z., Kaneko, T., & Somogyi, P. (1996). Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. Nature, 381(6582), 523-525. https://doi.org/10.1038/381523a0

Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. / Shigemoto, Ryuichi; Kulik, Akos; Roberts, J. David B; Ohishi, Hitoshi; Nusser, Z.; Kaneko, Takeshi; Somogyi, Peter.

In: Nature, Vol. 381, No. 6582, 1996, p. 523-525.

Research output: Contribution to journalArticle

Shigemoto, R, Kulik, A, Roberts, JDB, Ohishi, H, Nusser, Z, Kaneko, T & Somogyi, P 1996, 'Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone', Nature, vol. 381, no. 6582, pp. 523-525. https://doi.org/10.1038/381523a0
Shigemoto, Ryuichi ; Kulik, Akos ; Roberts, J. David B ; Ohishi, Hitoshi ; Nusser, Z. ; Kaneko, Takeshi ; Somogyi, Peter. / Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. In: Nature. 1996 ; Vol. 381, No. 6582. pp. 523-525.
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