Tandem Sonogashira coupling: An efficient tool for the synthesis of diarylalkynes

Zoltán Novák, Péter Nemes, András Kotschy

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98 Citations (Scopus)

Abstract

(Chemical Equation Presented) The tandem Sonogashira coupling reaction of aryl halides provides an efficient method for the synthesis of diarylalkynes. Several aryl halides were coupled with 2-methyl-3-butyn-2-ol as acetylene source in the presence of PdCl2(PPh3)2 and CuI. Following the deprotection of the acetylene moiety in the same pot using a strong base, the Sonogashira coupling of a second aryl halide led to the formation of the appropriate diarylakyne. The established protocoll was successfully extended to the preparation of compound libraries.

Original languageEnglish
Pages (from-to)4917-4920
Number of pages4
JournalOrganic Letters
Volume6
Issue number26
DOIs
Publication statusPublished - Dec 23 2004

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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