Tandem LA-LIBS coupled to ICP-MS for comprehensive analysis of tumor samples

Maximilian Bonta, Szilvia Török, B. Döme, Andreas Limbeck

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3 Citations (Scopus)

Abstract

Elemental imaging is regarded as a valuable approach for a wide application range in modern medicine. Using tandem laser-ablation laser-induced breakdown spectroscopy (LA-LIBS) coupled to inductively coupled plasma-mass spectrometry (ICP-MS), high-sensitivity detection of trace metals can be combined with the possibility of analyzing nonmetallic bulk components of biological samples (for example, carbon, hydrogen, and oxygen). In this work, the applicability of the tandem LA-LIBS approach for the laterally resolved elemental analysis of a mouse model tumor sample after administering cytostatic medication is demonstrated. Results show that trace elements can be detected using the LA-ICP-MS domain of the setup while major components of the samples are analyzed simultaneously using LIBS. By expanding the analyte range covered during one analysis, information could be extracted from the data set that is not accessible to either of the stand-alone analysis methods.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalSpectroscopy (Santa Monica)
Volume32
Issue number10
Publication statusPublished - Oct 1 2017

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Spectroscopy

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