Taking the sting out of pain

I. Nagy, C. Paule, J. White, L. Urban

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

While the role of the brain kallikrein-kinin system in the development of various pathological processes, such as oedema formation following brain injury or induction of central hypertonia has generated major interest, the possible role of this system in nociceptive processing has received little attention. In their present paper, Mortari et al. (2007) show that bradykinin B2 receptor activation in the brain by the bradykinin analogue, Thr 6-bradykinin, isolated from the venom of the social wasp, Polybia occidentalis potently reduces acute, noxious heat-evoked reflex responses in naive rats. The unknown underlying mechanism of this powerful antinociceptive effect reminds us that the supraspinal antinociceptive system is still a "black box" in many aspects and awaits thorough investigation.

Original languageEnglish
Pages (from-to)721-722
Number of pages2
JournalBritish Journal of Pharmacology
Volume151
Issue number6
DOIs
Publication statusPublished - Jul 2007

Fingerprint

Thr(6)-bradykinin
Bites and Stings
Wasp Venoms
Bradykinin B2 Receptors
Kallikrein-Kinin System
Pain
Brain
Bradykinin
Pathologic Processes
Brain Injuries
Reflex
Edema
Hot Temperature

Keywords

  • Amygdala
  • Bradykinin
  • Brain
  • Locus coeruleus
  • Pain
  • Periaqueductal grey

ASJC Scopus subject areas

  • Pharmacology

Cite this

Taking the sting out of pain. / Nagy, I.; Paule, C.; White, J.; Urban, L.

In: British Journal of Pharmacology, Vol. 151, No. 6, 07.2007, p. 721-722.

Research output: Contribution to journalArticle

Nagy, I, Paule, C, White, J & Urban, L 2007, 'Taking the sting out of pain', British Journal of Pharmacology, vol. 151, no. 6, pp. 721-722. https://doi.org/10.1038/sj.bjp.0707274
Nagy, I. ; Paule, C. ; White, J. ; Urban, L. / Taking the sting out of pain. In: British Journal of Pharmacology. 2007 ; Vol. 151, No. 6. pp. 721-722.
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