Tagging SNP association study of the IL-1β gene (IL1B) and childhood-onset mood disorders

Virginia L. Misener, Lissette Gomez, Karen G. Wigg, Nicole King, Eniko Kiss, Gabriella Daróczi, Krisztina Kapornai, Zsuzsanna Tamás, László Mayer, Júlia Gádoros, Ildikó Baji, James L. Kennedy, Maria Kovacs, Ágnes Vetró, Cathy L. Barr, István Benák, Viola Kothencné Osváth, Edit Dombovári, Emília Kaczvinszky, Márta BesnyoJudit Székely

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13 Citations (Scopus)

Abstract

Given substantial evidence for IL-1β involvement in the etiology of depression, the IL1B gene is a strong candidate for involvement in susceptibility to depressive disorders. However, association studies investigating this, to date, have been limited to just two polymorphisms (rs1143627[-31T/C] and rs16944[-511C/ T]) that constitute only a fraction of the genetic variation that is actually present across this gene in the population. Here, in a family-based association study of childhood-onset mood disorders (COMD), characterized by onset of depression before the age of 15, we have used a gene-wide approach, employing a panel of five tagging SNPs spanning the entire gene. Based on TDT analyses of both individual alleles and haplotypes, in a study sample of 646 families (with 782 affected children), none of the SNPs, including those implicated in transcriptional regulation of the gene, showed evidence for association with COMD. This is the largest and most comprehensive study of IL1B in relation to mood disorders that has been carried out, to date. The results do not support the involvement of IL1B as amajor factor in genetic risk for early-onset mood disorders.

Original languageEnglish
Pages (from-to)653-659
Number of pages7
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume150
Issue number5
DOIs
Publication statusPublished - Jul 5 2009

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Keywords

  • Childhood
  • Genetics
  • Il-1β depression
  • Inflammatory cytokine

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Misener, V. L., Gomez, L., Wigg, K. G., King, N., Kiss, E., Daróczi, G., Kapornai, K., Tamás, Z., Mayer, L., Gádoros, J., Baji, I., Kennedy, J. L., Kovacs, M., Vetró, Á., Barr, C. L., Benák, I., Osváth, V. K., Dombovári, E., Kaczvinszky, E., ... Székely, J. (2009). Tagging SNP association study of the IL-1β gene (IL1B) and childhood-onset mood disorders. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 150(5), 653-659. https://doi.org/10.1002/ajmg.b.30885