Tabernines A-C, β-carbolines from the leaves of Tabernaemontana elegans

Tayyab A. Mansoor, Cátia Ramalhete, Joseph Molnár, Silva Mulhovo, Maria José U. Ferreira

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Three novel α-carboline indole alkaloids (1-3) have been isolated from a MeOH extract of the leaves of Tabernaemontana elegans. The structures were established by means of spectroscopic techniques including 2D NMR experiments. Compounds 1 and 2 contain a two-carbon unit, attached to a structurally related β-carboline skeleton, as part of an additional six-membered ring in 1 and a seven-membered ring in 2. To the best of our knowledge, this is the first report of β-carboline indole alkaloids from the genus Tabernaemontana. Compounds 1-3 were evaluated for their ability to modulate multidrug resistance in mouse lymphoma cell lines. Compounds 1 and 3 exhibited a weak activity.

Original languageEnglish
Pages (from-to)1147-1150
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number6
DOIs
Publication statusPublished - Jun 26 2009

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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