T3P®-assisted esterification and amidation of phosphinic acids

Erzsébet Jablonkai, Réka Henyecz, Mátyás Milen, János Kóti, György Keglevich

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A few phosphinic acids, such as phenylphosphinic acids, 1-hydroxy-3-phospholene 1-oxides and 1-hydroxyphospholane oxides are esterified with simple alcohols in the presence of propylphosphonic anhydride (T3P®). If 1.1 equiv of the T3P® reagent is used, the esterifications are fast and efficient at 25° C. In the case of more reactive models it was enough to apply 0.66 equiv of T3P® at 85°C under microwave conditions. The amidation of 1-hydroxy-3-methyl-3-phospholene oxide could also be accomplished under similar conditions.

Original languageEnglish
Pages (from-to)8280-8285
Number of pages6
JournalTetrahedron
Volume70
Issue number44
DOIs
Publication statusPublished - Nov 4 2014

Keywords

  • Green synthesis
  • P-Heterocycles
  • Phosphinate
  • Phosphinic acid
  • Phosphinic amide
  • T3P reagent

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'T3P<sup>®</sup>-assisted esterification and amidation of phosphinic acids'. Together they form a unique fingerprint.

  • Cite this