T3P®-assisted esterification and amidation of phosphinic acids

Erzsébet Jablonkai, Réka Henyecz, Mátyás Milen, János Kóti, G. Keglevich

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A few phosphinic acids, such as phenylphosphinic acids, 1-hydroxy-3-phospholene 1-oxides and 1-hydroxyphospholane oxides are esterified with simple alcohols in the presence of propylphosphonic anhydride (T3P®). If 1.1 equiv of the T3P® reagent is used, the esterifications are fast and efficient at 25° C. In the case of more reactive models it was enough to apply 0.66 equiv of T3P® at 85°C under microwave conditions. The amidation of 1-hydroxy-3-methyl-3-phospholene oxide could also be accomplished under similar conditions.

Original languageEnglish
Pages (from-to)8280-8285
Number of pages6
JournalTetrahedron
Volume70
Issue number44
DOIs
Publication statusPublished - Nov 4 2014

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Phosphinic Acids
Esterification
Oxides
Anhydrides
Microwaves
Alcohols

Keywords

  • Green synthesis
  • P-Heterocycles
  • Phosphinate
  • Phosphinic acid
  • Phosphinic amide
  • T3P reagent

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

T3P®-assisted esterification and amidation of phosphinic acids. / Jablonkai, Erzsébet; Henyecz, Réka; Milen, Mátyás; Kóti, János; Keglevich, G.

In: Tetrahedron, Vol. 70, No. 44, 04.11.2014, p. 8280-8285.

Research output: Contribution to journalArticle

Jablonkai, E, Henyecz, R, Milen, M, Kóti, J & Keglevich, G 2014, 'T3P®-assisted esterification and amidation of phosphinic acids', Tetrahedron, vol. 70, no. 44, pp. 8280-8285. https://doi.org/10.1016/j.tet.2014.09.021
Jablonkai, Erzsébet ; Henyecz, Réka ; Milen, Mátyás ; Kóti, János ; Keglevich, G. / T3P®-assisted esterification and amidation of phosphinic acids. In: Tetrahedron. 2014 ; Vol. 70, No. 44. pp. 8280-8285.
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