T3P®-promoted Kabachnik-Fields reaction: An efficient synthesis of α-aminophosphonates

Mátyás Milen, Péter Ábrányi-Balogh, András Dancsó, Dávid Frigyes, László Pongó, György Keglevich

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A simple and efficient synthesis of α-aminophosphonates has been developed via the one-pot three-component reactions of aldehydes, amines, and trialkyl phosphites. The reactions occurred rapidly at room temperature in the presence of 1 equiv of propylphosphonic anhydride (T3P®) as the condensing agent, and the α-aminophosphonate products were obtained in high yields.

Original languageEnglish
Pages (from-to)5430-5433
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number40
DOIs
Publication statusPublished - Oct 2 2013

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Keywords

  • Kabachnik-Fields reaction
  • Mechanism
  • T3P®
  • Three-component condensation
  • α-Aminophosphonates

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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