T cells with regulatory activity in hepatitis C virus infection: What we know and what we don't

Angela Dolganiuc, G. Szabó

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

The mechanism behind the apparent lack of effective antiviral immune response in patients with chronic hepatitis C virus (HCV) infection is poorly understood. Although multiple levels of abnormalities have been identified in innate and adaptive immunity, it remains unclear if any of the subpopulations of T cells with regulatory capacity (Tregs) contribute to the induction and maintenance of HCV persistence. In this review, we summarize the current knowledge about Tregs as they relate to HCV infection.

Original languageEnglish
Pages (from-to)614-622
Number of pages9
JournalJournal of Leukocyte Biology
Volume84
Issue number3
DOIs
Publication statusPublished - Sep 1 2008

Fingerprint

Virus Diseases
Regulatory T-Lymphocytes
Hepacivirus
Multiple Abnormalities
Adaptive Immunity
Chronic Hepatitis C
Innate Immunity
Antiviral Agents
Maintenance

Keywords

  • CD8
  • FoxP3
  • IL-10
  • Liver
  • TGF-β
  • Th3
  • Tr1
  • Tregs

ASJC Scopus subject areas

  • Cell Biology

Cite this

T cells with regulatory activity in hepatitis C virus infection : What we know and what we don't. / Dolganiuc, Angela; Szabó, G.

In: Journal of Leukocyte Biology, Vol. 84, No. 3, 01.09.2008, p. 614-622.

Research output: Contribution to journalReview article

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