T cell receptor Vβ gene utilization in myelin basic protein specific clones from CXJ1 recombinant inbred mice

B. Kálmán, Robert L. Knobler, Fred D. Lublin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

CXJ1 mice are a recombinant inbred strain generated from experimental allergic encephalomyelitis (EAE) resistant BALB/c and EAE susceptible SJL/J progenitors. CXJ1 derive their major histocompatibility complex (MHC) class II and TCR genes from the BALB/c progenitor. However, their susceptibility to EAE is similar to SJL/J. Utilizing myelin basic protein (MBP)-specific CD4+ hybridoma clones and a MBP-specific T cell line (TCL) from CXJ1, we found the predominant T cell receptor (TCR) Vβ chain expression to be Vβ8 and Vβ13. Our data support the concept of preferential, but not exclusive, TCR Vβ usage in the MBP-specific response which is independent of MHC class II haplotype or immunodominant peptide.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalJournal of Neuroimmunology
Volume43
Issue number1-2
DOIs
Publication statusPublished - 1993

Fingerprint

T-Cell Receptor Genes
Myelin Basic Protein
Autoimmune Experimental Encephalomyelitis
Clone Cells
T-Cell Antigen Receptor
Major Histocompatibility Complex
Hybridomas
Haplotypes
T-Lymphocytes
Cell Line
Peptides

Keywords

  • Experimental allergic encephalomyelitis
  • Recombinant inbred mice
  • T cell receptor

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

T cell receptor Vβ gene utilization in myelin basic protein specific clones from CXJ1 recombinant inbred mice. / Kálmán, B.; Knobler, Robert L.; Lublin, Fred D.

In: Journal of Neuroimmunology, Vol. 43, No. 1-2, 1993, p. 191-194.

Research output: Contribution to journalArticle

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