T and B lymphocytes in lymph nodes and spleen of patients with Hodgkin's disease

E. Berenyi, I. Sonkoly, K. Pálóczi, G. Balázs, G. Szegedi

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Abstract

Lymphocyte surface markers of 100 tissue specimens (67 lymph nodes and 33 spleens) of 40 patients with Hodgkin's disease were studied by means of spontaneous E-rosette formation and direct immunofluorescence method. The occurrence of active and total T cells was significantly higher (p <0.001) in the tumor-involved lymph nodes and spleens, while the frequency of B cells was practically the same as in the histologically negative lymph nodes and spleens. In the tumorous spleen of 6 untreated patients the frequency of active and total T cells was higher in the tumorous tissue specimens than in the surrounding histologically negative tissue specimens. No correlation has been found between the simultaneously investigated peripheral T and B cell counts, clinical stage and the histological type of the tumor.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalNeoplasma
Volume26
Issue number3
Publication statusPublished - 1979

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Hodgkin Disease
B-Lymphocytes
Spleen
Lymph Nodes
T-Lymphocytes
Rosette Formation
Direct Fluorescent Antibody Technique
Neoplasms
Cell Count
Lymphocytes

ASJC Scopus subject areas

  • Cancer Research

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T and B lymphocytes in lymph nodes and spleen of patients with Hodgkin's disease. / Berenyi, E.; Sonkoly, I.; Pálóczi, K.; Balázs, G.; Szegedi, G.

In: Neoplasma, Vol. 26, No. 3, 1979, p. 307-313.

Research output: Contribution to journalArticle

Berenyi, E. ; Sonkoly, I. ; Pálóczi, K. ; Balázs, G. ; Szegedi, G. / T and B lymphocytes in lymph nodes and spleen of patients with Hodgkin's disease. In: Neoplasma. 1979 ; Vol. 26, No. 3. pp. 307-313.
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