Systems-level feedback in cell-cycle control

Béla Novk, P. K. Vinod, Paula Freire, O. Kapuy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Alternation of chromosome replication and segregation is essential for successful completion of the cell cycle and it requires an oscillation of Cdk1 (cyclin-dependent kinase 1)-CycB (cyclin B) activity. In the present review, we illustrate the essential features of checkpoint controlled and uncontrolled cell-cycle oscillations by using mechanical metaphors. Despite variations in the molecular details of the oscillatory mechanism, the underlying network motifs responsible for the oscillations are always well-conserved. The checkpoint-controlled cell cycles are always driven by a negative-feedback loop amplified by double-negative feedbacks (antagonism).

Original languageEnglish
Pages (from-to)1242-1246
Number of pages5
JournalBiochemical Society Transactions
Volume38
Issue number5
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Cell Cycle Checkpoints
Cell Cycle
Cells
CDC2 Protein Kinase
Cyclin B
Feedback
Chromosome Segregation
Metaphor
Chromosomes

Keywords

  • Bistability
  • Cell cycle
  • Feedback
  • Oscillation

ASJC Scopus subject areas

  • Biochemistry

Cite this

Systems-level feedback in cell-cycle control. / Novk, Béla; Vinod, P. K.; Freire, Paula; Kapuy, O.

In: Biochemical Society Transactions, Vol. 38, No. 5, 10.2010, p. 1242-1246.

Research output: Contribution to journalArticle

Novk, Béla ; Vinod, P. K. ; Freire, Paula ; Kapuy, O. / Systems-level feedback in cell-cycle control. In: Biochemical Society Transactions. 2010 ; Vol. 38, No. 5. pp. 1242-1246.
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