Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis

A. Párdutz, I. Krizbai, S. Multon, L. Vécsei, J. Schoenen

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Systemic administration of nitroglycerin, a nitric oxide donor, triggers in migraineurs a delayed attack of unknown mechanisms. Subcutaneous nitroglycerin (10 mg/kg) produced a significant increase of nitric oxide synthase (NOS)- and c-fos-immunoreactive neurons in the cervical part of trigeminal nucleus caudalis in rats after 4 h. This effect was not observed in the thoracic dorsal horn. Similar increase of NOS and c-fos was obtained in the brain stem after a somatic nociceptive stimulus, i.e. on the side of the formalin injection in the lip. Nitric oxide is thus able to increase NOS availability in second order nociceptive trigeminal neurons, which may be relevant for central sensitization and the understanding of its effect in migraine. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)3071-3075
Number of pages5
JournalNeuroReport
Volume11
Issue number14
Publication statusPublished - Oct 28 2000

Fingerprint

Trigeminal Nuclei
Nitroglycerin
Nitric Oxide Synthase
Central Nervous System Sensitization
Nociceptors
Nitric Oxide Donors
Lip
Migraine Disorders
Formaldehyde
Brain Stem
Nitric Oxide
Thorax
Neurons
Injections

Keywords

  • Migraine
  • Nitric oxide synthase
  • Nitroglycerin
  • Trigeminovascular system

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis. / Párdutz, A.; Krizbai, I.; Multon, S.; Vécsei, L.; Schoenen, J.

In: NeuroReport, Vol. 11, No. 14, 28.10.2000, p. 3071-3075.

Research output: Contribution to journalArticle

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