Szisztémás lupus erythematosus és terhesség (prekoncepcionális haematológiai rendellenességek hatása a magzati eredményekre).

Translated title of the contribution: Systemic lupus erythematosus and pregnancy (effect of pre-conception hematologic disorders on fetal outcome)

A. Pajor, T. Pozsonyi, K. Nékám, L. Bakos, L. Haraszti, F. Paulin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of the study was to determine the fetal and neonatal outcomes of pregnancies conceived during the inactive phase of systemic lupus erythematosus (SLE). Fetal and neonatal outcomes in 75 pregnancies of 33 patients with SLE were analyzed. In 19 patients (57.6%) the SLE also had hematological autoimmune presentations prior to gestation, such as anemia, thrombopenia, garnulocytopenia, and antiphospholipid antibody and/or lupus anticoagulant (APA). Out of 75 pregnancies, 19 elective terminations were carried out because the disease was active or for non-medical reasons. The adverse fetal outcomes of those 56 pregnancies which occurred during the inactive phase were compared with those of the control patients. In SLE, the rates of spontaneous abortions (46.4%) and newborns with low (<2500 gr) birthweight (36.7%) were found to increase roughly three times that of the controls and the perinatal fetal loss (16.7%) also increased significantly as compared with the control group (28.5 per thousand). APA noted at any time before pregnancy increased the low birthweight rate (75%) six fold and the perinatal loss (33.3%) more than ten fold but did not affect the rate of spontaneous abortions. Any kind of hemocytopenias without APA, noted before pregnancy did not worsen the fetal outcome in SLE. Neonatal lupus was diagnosed in 2 out of the 30 newborns. Our results suggest that among the hematologic manifestations of SLE presenting before pregnancy, APA can predict the high risks of low birthweight and perinatal fetal loss as opposed to hemocytopenias.

Original languageHungarian
Pages (from-to)415-418
Number of pages4
JournalOrvosi Hetilap
Volume139
Issue number8
Publication statusPublished - Feb 22 1998

Fingerprint

Systemic Lupus Erythematosus
Pregnancy
Spontaneous Abortion
Newborn Infant
Lupus Coagulation Inhibitor
Antiphospholipid Antibodies
Pregnancy Outcome
Thrombocytopenia
Anemia
Control Groups

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szisztémás lupus erythematosus és terhesség (prekoncepcionális haematológiai rendellenességek hatása a magzati eredményekre). / Pajor, A.; Pozsonyi, T.; Nékám, K.; Bakos, L.; Haraszti, L.; Paulin, F.

In: Orvosi Hetilap, Vol. 139, No. 8, 22.02.1998, p. 415-418.

Research output: Contribution to journalArticle

Pajor, A. ; Pozsonyi, T. ; Nékám, K. ; Bakos, L. ; Haraszti, L. ; Paulin, F. / Szisztémás lupus erythematosus és terhesség (prekoncepcionális haematológiai rendellenességek hatása a magzati eredményekre). In: Orvosi Hetilap. 1998 ; Vol. 139, No. 8. pp. 415-418.
@article{26938a5927494705812ec1a0e1c63efc,
title = "Sziszt{\'e}m{\'a}s lupus erythematosus {\'e}s terhess{\'e}g (prekoncepcion{\'a}lis haematol{\'o}giai rendelleness{\'e}gek hat{\'a}sa a magzati eredm{\'e}nyekre).",
abstract = "The aim of the study was to determine the fetal and neonatal outcomes of pregnancies conceived during the inactive phase of systemic lupus erythematosus (SLE). Fetal and neonatal outcomes in 75 pregnancies of 33 patients with SLE were analyzed. In 19 patients (57.6{\%}) the SLE also had hematological autoimmune presentations prior to gestation, such as anemia, thrombopenia, garnulocytopenia, and antiphospholipid antibody and/or lupus anticoagulant (APA). Out of 75 pregnancies, 19 elective terminations were carried out because the disease was active or for non-medical reasons. The adverse fetal outcomes of those 56 pregnancies which occurred during the inactive phase were compared with those of the control patients. In SLE, the rates of spontaneous abortions (46.4{\%}) and newborns with low (<2500 gr) birthweight (36.7{\%}) were found to increase roughly three times that of the controls and the perinatal fetal loss (16.7{\%}) also increased significantly as compared with the control group (28.5 per thousand). APA noted at any time before pregnancy increased the low birthweight rate (75{\%}) six fold and the perinatal loss (33.3{\%}) more than ten fold but did not affect the rate of spontaneous abortions. Any kind of hemocytopenias without APA, noted before pregnancy did not worsen the fetal outcome in SLE. Neonatal lupus was diagnosed in 2 out of the 30 newborns. Our results suggest that among the hematologic manifestations of SLE presenting before pregnancy, APA can predict the high risks of low birthweight and perinatal fetal loss as opposed to hemocytopenias.",
author = "A. Pajor and T. Pozsonyi and K. N{\'e}k{\'a}m and L. Bakos and L. Haraszti and F. Paulin",
year = "1998",
month = "2",
day = "22",
language = "Hungarian",
volume = "139",
pages = "415--418",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "8",

}

TY - JOUR

T1 - Szisztémás lupus erythematosus és terhesség (prekoncepcionális haematológiai rendellenességek hatása a magzati eredményekre).

AU - Pajor, A.

AU - Pozsonyi, T.

AU - Nékám, K.

AU - Bakos, L.

AU - Haraszti, L.

AU - Paulin, F.

PY - 1998/2/22

Y1 - 1998/2/22

N2 - The aim of the study was to determine the fetal and neonatal outcomes of pregnancies conceived during the inactive phase of systemic lupus erythematosus (SLE). Fetal and neonatal outcomes in 75 pregnancies of 33 patients with SLE were analyzed. In 19 patients (57.6%) the SLE also had hematological autoimmune presentations prior to gestation, such as anemia, thrombopenia, garnulocytopenia, and antiphospholipid antibody and/or lupus anticoagulant (APA). Out of 75 pregnancies, 19 elective terminations were carried out because the disease was active or for non-medical reasons. The adverse fetal outcomes of those 56 pregnancies which occurred during the inactive phase were compared with those of the control patients. In SLE, the rates of spontaneous abortions (46.4%) and newborns with low (<2500 gr) birthweight (36.7%) were found to increase roughly three times that of the controls and the perinatal fetal loss (16.7%) also increased significantly as compared with the control group (28.5 per thousand). APA noted at any time before pregnancy increased the low birthweight rate (75%) six fold and the perinatal loss (33.3%) more than ten fold but did not affect the rate of spontaneous abortions. Any kind of hemocytopenias without APA, noted before pregnancy did not worsen the fetal outcome in SLE. Neonatal lupus was diagnosed in 2 out of the 30 newborns. Our results suggest that among the hematologic manifestations of SLE presenting before pregnancy, APA can predict the high risks of low birthweight and perinatal fetal loss as opposed to hemocytopenias.

AB - The aim of the study was to determine the fetal and neonatal outcomes of pregnancies conceived during the inactive phase of systemic lupus erythematosus (SLE). Fetal and neonatal outcomes in 75 pregnancies of 33 patients with SLE were analyzed. In 19 patients (57.6%) the SLE also had hematological autoimmune presentations prior to gestation, such as anemia, thrombopenia, garnulocytopenia, and antiphospholipid antibody and/or lupus anticoagulant (APA). Out of 75 pregnancies, 19 elective terminations were carried out because the disease was active or for non-medical reasons. The adverse fetal outcomes of those 56 pregnancies which occurred during the inactive phase were compared with those of the control patients. In SLE, the rates of spontaneous abortions (46.4%) and newborns with low (<2500 gr) birthweight (36.7%) were found to increase roughly three times that of the controls and the perinatal fetal loss (16.7%) also increased significantly as compared with the control group (28.5 per thousand). APA noted at any time before pregnancy increased the low birthweight rate (75%) six fold and the perinatal loss (33.3%) more than ten fold but did not affect the rate of spontaneous abortions. Any kind of hemocytopenias without APA, noted before pregnancy did not worsen the fetal outcome in SLE. Neonatal lupus was diagnosed in 2 out of the 30 newborns. Our results suggest that among the hematologic manifestations of SLE presenting before pregnancy, APA can predict the high risks of low birthweight and perinatal fetal loss as opposed to hemocytopenias.

UR - http://www.scopus.com/inward/record.url?scp=0032557001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032557001&partnerID=8YFLogxK

M3 - Article

VL - 139

SP - 415

EP - 418

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 8

ER -