A terápiás célú teljestest-hypothermia szisztémás és immunmoduláns hatásai

Translated title of the contribution: Systemic and immunomodulatory effects of whole body therapeutic hypothermia

Vince Pongor, Gergely Toldi, M. Szabó, B. Vásárhelyi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Several neurobiological mechanisms contribute to the development of ischemic-reperfusion damage of the central nervous system that may be modulated by hypothermia. Nowadays hypothermia is a therapeutic tool for the treatment of stroke and perinatal asphyxia. Hypothermia does not only affect the central nervous system, but also has systemic effects. It influences the muscular and cardiovascular system, the systematic metabolism, induces electrolyte changes, and decreases inflammation. This review summarizes the effects of therapeutic hypothermia on the immune system. Experiments on cell lines and in animals along with human experience indicate that short term (2-4 hours) hypothermia increases the levels of anti-inflammatory cytokines and decreases that of proinflammatory cytokines. Long term (>24 hours) hypothermia, however, increases proinflammatory cytokine levels. Furthermore, hypothermia inhibits lymphocyte proliferation and decreases HLA-DR expression associated with cell activation. These results suggest that therapeutic hypothermia has a systemic immunomodulatory effect. Further research is required to determine the contribution of immunomodulation to the defense of the central nervous system.

Original languageHungarian
Pages (from-to)575-580
Number of pages6
JournalOrvosi Hetilap
Volume152
Issue number15
DOIs
Publication statusPublished - Apr 1 2011

Fingerprint

Induced Hypothermia
Hypothermia
Central Nervous System
Cytokines
Immunomodulation
Asphyxia
HLA-DR Antigens
Cardiovascular System
Reperfusion Injury
Electrolytes
Immune System
Anti-Inflammatory Agents
Stroke
Lymphocytes
Inflammation
Cell Line
Therapeutics
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A terápiás célú teljestest-hypothermia szisztémás és immunmoduláns hatásai. / Pongor, Vince; Toldi, Gergely; Szabó, M.; Vásárhelyi, B.

In: Orvosi Hetilap, Vol. 152, No. 15, 01.04.2011, p. 575-580.

Research output: Contribution to journalArticle

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