Systematic review of fatty acid composition of human milk from mothers of preterm compared to full-term infants

Szilvia Bokor, Berthold Koletzko, Tamás Decsi

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Background: Fatty acid composition of human milk serves as guidance for the composition of infant formulae. The aim of the study was to systematically review data on the fatty acid composition of human milk of mothers of preterm compared to full-term infants. Methods: An electronic literature search was performed in English (Medline and Medscape) and German (SpringerLink) databases and via the Google utility. Fatty acid compositional data for preterm and full-term human milk were converted to differences between means and 95% confidence intervals. Results: We identified five relevant studies publishing direct comparison of fatty acid composition of preterm versus full-term human milk. There were no significant differences between the values of the principal saturated and monounsaturated fatty acids. In three independent studies covering three different time points of lactation, however, docosahexaenoic acid (DHA) values were significantly higher in milk of mothers of preterm as compared to those of full-term infants, with an extent of difference considered nutritionally relevant. Conclusion: Higher DHA values in preterm than in full-term human milk underlines the importance of using own mother's milk for feeding preterm babies and raises the question whether DHA contents in preterm formulae should be higher than in formulae for full-term infants.

Original languageEnglish
Pages (from-to)550-556
Number of pages7
JournalAnnals of Nutrition and Metabolism
Volume51
Issue number6
DOIs
Publication statusPublished - Feb 1 2007

Keywords

  • Essential fatty acid
  • Full-term infant
  • Human milk
  • Long-chain polyunsaturated fatty acid
  • Preterm infant

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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