Systematic review and meta-Analysis of colon cleansing preparations in patients with inflammatory bowel disease

Sophie Restellini, Omar Kherad, Talat Bessissow, Charles Ménard, Myriam Martel, Maryam Taheri Tanjani, P. Lakatos, Alan N. Barkun

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

AIM To performed a systematic review and meta-Analysis to determine any possible differences in terms of effectiveness, safety and tolerability between existing colon-cleansing products in patients with inflammatory bowel disease. METHODS Systematic searches were performed (January 1980-September 2016) using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge for randomized trials assessing preparations with or without adjuvants, given in split and non-split dosing, and in high (> 3 L) or low-volume (2 L or less) regimens. Bowel cleansing quality was the primary outcome. Secondary outcomes included patient willingness-Torepeat the procedure and side effects/complications. RESULTS Out of 439 citations, 4 trials fulfilled our inclusion criteria (n = 449 patients). One trial assessed the impact of adding simethicone to polyethylene glycol (PEG) 4 L with no effect on bowel cleansing quality, but a better tolerance. Another trial compared senna to castor oil, again without any differences in term of bowel cleansing. Two trials compared the efficacy of PEG high-volume vs PEG low-volume associated to an adjuvant in split-dose regimens: PEG low-dose efficacy was not different to PEG high-dose; OR = 0.84 (0.37-1.92). A higher proportion of patients were willing to repeat low-volume preparations vs high-volume; OR = 5.11 (1.31-20.0). CONCLUSION In inflammatory bowel disease population, PEG lowvolume regimen seems not inferior to PEG high-volume to clean the colon, and yields improved willingness-Torepeat. Further additional research is urgently required to compare contemporary products in this population.

Original languageEnglish
Pages (from-to)5994-6002
Number of pages9
JournalWorld journal of gastroenterology
Volume23
Issue number32
DOIs
Publication statusPublished - Aug 28 2017

Fingerprint

Inflammatory Bowel Diseases
Meta-Analysis
Colon
Simethicone
Castor Oil
MEDLINE
Population
Safety
Research

Keywords

  • Colonoscopy
  • Inflammatory bowel disease
  • Meta-Analysis
  • Polyethylene glycol

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Restellini, S., Kherad, O., Bessissow, T., Ménard, C., Martel, M., Tanjani, M. T., ... Barkun, A. N. (2017). Systematic review and meta-Analysis of colon cleansing preparations in patients with inflammatory bowel disease. World journal of gastroenterology, 23(32), 5994-6002. https://doi.org/10.3748/wjg.v23.i32.5994

Systematic review and meta-Analysis of colon cleansing preparations in patients with inflammatory bowel disease. / Restellini, Sophie; Kherad, Omar; Bessissow, Talat; Ménard, Charles; Martel, Myriam; Tanjani, Maryam Taheri; Lakatos, P.; Barkun, Alan N.

In: World journal of gastroenterology, Vol. 23, No. 32, 28.08.2017, p. 5994-6002.

Research output: Contribution to journalArticle

Restellini, S, Kherad, O, Bessissow, T, Ménard, C, Martel, M, Tanjani, MT, Lakatos, P & Barkun, AN 2017, 'Systematic review and meta-Analysis of colon cleansing preparations in patients with inflammatory bowel disease', World journal of gastroenterology, vol. 23, no. 32, pp. 5994-6002. https://doi.org/10.3748/wjg.v23.i32.5994
Restellini, Sophie ; Kherad, Omar ; Bessissow, Talat ; Ménard, Charles ; Martel, Myriam ; Tanjani, Maryam Taheri ; Lakatos, P. ; Barkun, Alan N. / Systematic review and meta-Analysis of colon cleansing preparations in patients with inflammatory bowel disease. In: World journal of gastroenterology. 2017 ; Vol. 23, No. 32. pp. 5994-6002.
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AU - Lakatos, P.

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