Synthetic tripeptides with anorexogenic effect

T. Szirtes, B. Knoll, L. Kisfaludy, J. Knoll

Research output: Contribution to journalArticle

Abstract

Thirty two synthetic tripeptides structurally related both to thyrotropin releasing hormone (TRH) and anorexogenic tripeptide (Glp-His-Gly-OH) were investigated for anorexogenic effect in rats. While the two endogenous peptides, TRH and Glp-His-Gly-OH, were ineffective in rats deprived of food for 96 hours when they were administered intracerebroventricularly, some of the synthetic analogues showed significant food intake reducing effect under the same conditions. This anorexogenic effect of the tripeptides is similar - though much weaker - to that of satietin, a highly potent anorexogenic glycopeptide in human and mammalian serum. These tripeptides were ineffective when they were administered intravenously.

Original languageEnglish
Pages (from-to)339-345
Number of pages7
JournalPolish Journal of Pharmacology and Pharmacy
Volume34
Issue number5-6
Publication statusPublished - 1982

Fingerprint

histidylglycine
Thyrotropin-Releasing Hormone
Glycopeptides
Eating
Food
Peptides
Serum

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Szirtes, T., Knoll, B., Kisfaludy, L., & Knoll, J. (1982). Synthetic tripeptides with anorexogenic effect. Polish Journal of Pharmacology and Pharmacy, 34(5-6), 339-345.

Synthetic tripeptides with anorexogenic effect. / Szirtes, T.; Knoll, B.; Kisfaludy, L.; Knoll, J.

In: Polish Journal of Pharmacology and Pharmacy, Vol. 34, No. 5-6, 1982, p. 339-345.

Research output: Contribution to journalArticle

Szirtes, T, Knoll, B, Kisfaludy, L & Knoll, J 1982, 'Synthetic tripeptides with anorexogenic effect', Polish Journal of Pharmacology and Pharmacy, vol. 34, no. 5-6, pp. 339-345.
Szirtes, T. ; Knoll, B. ; Kisfaludy, L. ; Knoll, J. / Synthetic tripeptides with anorexogenic effect. In: Polish Journal of Pharmacology and Pharmacy. 1982 ; Vol. 34, No. 5-6. pp. 339-345.
@article{53b998ee5ba6486685e400a86bfeacbf,
title = "Synthetic tripeptides with anorexogenic effect",
abstract = "Thirty two synthetic tripeptides structurally related both to thyrotropin releasing hormone (TRH) and anorexogenic tripeptide (Glp-His-Gly-OH) were investigated for anorexogenic effect in rats. While the two endogenous peptides, TRH and Glp-His-Gly-OH, were ineffective in rats deprived of food for 96 hours when they were administered intracerebroventricularly, some of the synthetic analogues showed significant food intake reducing effect under the same conditions. This anorexogenic effect of the tripeptides is similar - though much weaker - to that of satietin, a highly potent anorexogenic glycopeptide in human and mammalian serum. These tripeptides were ineffective when they were administered intravenously.",
author = "T. Szirtes and B. Knoll and L. Kisfaludy and J. Knoll",
year = "1982",
language = "English",
volume = "34",
pages = "339--345",
journal = "Pharmacological Reports",
issn = "1734-1140",
publisher = "Polish Academy of Sciences Publishing House",
number = "5-6",

}

TY - JOUR

T1 - Synthetic tripeptides with anorexogenic effect

AU - Szirtes, T.

AU - Knoll, B.

AU - Kisfaludy, L.

AU - Knoll, J.

PY - 1982

Y1 - 1982

N2 - Thirty two synthetic tripeptides structurally related both to thyrotropin releasing hormone (TRH) and anorexogenic tripeptide (Glp-His-Gly-OH) were investigated for anorexogenic effect in rats. While the two endogenous peptides, TRH and Glp-His-Gly-OH, were ineffective in rats deprived of food for 96 hours when they were administered intracerebroventricularly, some of the synthetic analogues showed significant food intake reducing effect under the same conditions. This anorexogenic effect of the tripeptides is similar - though much weaker - to that of satietin, a highly potent anorexogenic glycopeptide in human and mammalian serum. These tripeptides were ineffective when they were administered intravenously.

AB - Thirty two synthetic tripeptides structurally related both to thyrotropin releasing hormone (TRH) and anorexogenic tripeptide (Glp-His-Gly-OH) were investigated for anorexogenic effect in rats. While the two endogenous peptides, TRH and Glp-His-Gly-OH, were ineffective in rats deprived of food for 96 hours when they were administered intracerebroventricularly, some of the synthetic analogues showed significant food intake reducing effect under the same conditions. This anorexogenic effect of the tripeptides is similar - though much weaker - to that of satietin, a highly potent anorexogenic glycopeptide in human and mammalian serum. These tripeptides were ineffective when they were administered intravenously.

UR - http://www.scopus.com/inward/record.url?scp=0020260582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020260582&partnerID=8YFLogxK

M3 - Article

C2 - 6821217

AN - SCOPUS:0020260582

VL - 34

SP - 339

EP - 345

JO - Pharmacological Reports

JF - Pharmacological Reports

SN - 1734-1140

IS - 5-6

ER -