Synthesis, structure and in vitro cytostatic activity of ferrocene - Cinchona hybrids

László Kocsis, Ildikó Szabó, Sz. Bősze, Tamás Jernei, F. Hudecz, A. Csámpai

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Exploring copper(I)- and ruthenium(II)-catalyzed azide-alkyne cycloadditions and a Sonogashira protocol, novel cytostatic ferrocene-cinchona hybrids were synthetized displaying significant in vitro activity on HepG-2 and HT-29 cells. Preliminary SAR studies disclosed that compounds incorporating linkers with 1,2,3-triazole and chalchone residues can be considered as promising lead structures. According to the best of our knowledge this is the first letter on the incorporation of ferrocene nucleus in the reputed cinchona family via triazole and chalcone linkers with established pharmaceutical profile.

Original languageEnglish
Pages (from-to)946-949
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number3
DOIs
Publication statusPublished - 2016

    Fingerprint

Keywords

  • 1,2,3-Triazole
  • Cinchona
  • Click reaction
  • Cytostatic activity
  • Ferrocene

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this