Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues

Anna Adamska-Bartłomiejczyk, Attila Borics, C. Tömböly, Szabolcs Dvorácskó, Marek Lisowski, Alicja Kluczyk, Grzegorz Wołczański, Justyna Piekielna-Ciesielska, Anna Janecka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Three novel morphiceptin analogs, in which Pro in position 2 and/or 4 was replaced by cis-4-aminoproline connected with the preceding amino acid through the primary amino group, were synthesized. The opioid receptor affinities, functional assay results, enzymatic degradation studies and experimental and in silico structural analysis of such analogs are presented.

Original languageEnglish
Pages (from-to)864-870
Number of pages7
JournalJournal of Peptide Science
Volume23
Issue number12
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Enzyme Assays
Opioid Receptors
Proline
Structural analysis
Computer Simulation
Assays
Amino Acids
Degradation
morphiceptin
aminoproline

Keywords

  • binding assays
  • circular dichroism
  • ezymatic degradation
  • peptide synthesis
  • receptor docking

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues. / Adamska-Bartłomiejczyk, Anna; Borics, Attila; Tömböly, C.; Dvorácskó, Szabolcs; Lisowski, Marek; Kluczyk, Alicja; Wołczański, Grzegorz; Piekielna-Ciesielska, Justyna; Janecka, Anna.

In: Journal of Peptide Science, Vol. 23, No. 12, 01.12.2017, p. 864-870.

Research output: Contribution to journalArticle

Adamska-Bartłomiejczyk, A, Borics, A, Tömböly, C, Dvorácskó, S, Lisowski, M, Kluczyk, A, Wołczański, G, Piekielna-Ciesielska, J & Janecka, A 2017, 'Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues', Journal of Peptide Science, vol. 23, no. 12, pp. 864-870. https://doi.org/10.1002/psc.3050
Adamska-Bartłomiejczyk, Anna ; Borics, Attila ; Tömböly, C. ; Dvorácskó, Szabolcs ; Lisowski, Marek ; Kluczyk, Alicja ; Wołczański, Grzegorz ; Piekielna-Ciesielska, Justyna ; Janecka, Anna. / Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues. In: Journal of Peptide Science. 2017 ; Vol. 23, No. 12. pp. 864-870.
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