Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

B. Barta Holló, I. M. Szilágyi, C. Várhelyi, D. Hunyadi, R. I. Nagy, N. G. Tihi, F. Goga, J. Papp, R. Szalay, G. Pokol

Research output: Contribution to journalArticle

Abstract

Three complexes of general formula PtCl2R2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an)2Cl2] (1), [Pt(pa)2Cl2] (2) and [Pt(aph)2Cl2] (3), where an = 2-aminonaphthalene, pa = 2-aminopyrimidine, aph = 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI–MS and NMR), and tested against selected Gram(+) and Gram(–) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Thermal Analysis and Calorimetry
DOIs
Publication statusAccepted/In press - Jun 18 2016

Fingerprint

bacteria
Amines
Bacteria
amines
2-Naphthylamine
Ligands
ligands
synthesis
Powders
inhibitors
Differential thermal analysis
thermal analysis
Nitrogen
Thermodynamic properties
thermodynamic properties
Nuclear magnetic resonance
fragments
nitrogen
nuclear magnetic resonance
Water

Keywords

  • Amine ligand
  • Antimicrobial activity
  • Pt(II) complexes
  • Spectroscopic data
  • Thermal properties

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Condensed Matter Physics

Cite this

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands. / Barta Holló, B.; Szilágyi, I. M.; Várhelyi, C.; Hunyadi, D.; Nagy, R. I.; Tihi, N. G.; Goga, F.; Papp, J.; Szalay, R.; Pokol, G.

In: Journal of Thermal Analysis and Calorimetry, 18.06.2016, p. 1-9.

Research output: Contribution to journalArticle

Barta Holló, B. ; Szilágyi, I. M. ; Várhelyi, C. ; Hunyadi, D. ; Nagy, R. I. ; Tihi, N. G. ; Goga, F. ; Papp, J. ; Szalay, R. ; Pokol, G. / Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands. In: Journal of Thermal Analysis and Calorimetry. 2016 ; pp. 1-9.
@article{1fcbba77789346e79347f406d9d642d4,
title = "Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands",
abstract = "Three complexes of general formula PtCl2R2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an)2Cl2] (1), [Pt(pa)2Cl2] (2) and [Pt(aph)2Cl2] (3), where an = 2-aminonaphthalene, pa = 2-aminopyrimidine, aph = 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI–MS and NMR), and tested against selected Gram(+) and Gram(–) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria.",
keywords = "Amine ligand, Antimicrobial activity, Pt(II) complexes, Spectroscopic data, Thermal properties",
author = "{Barta Holl{\'o}}, B. and Szil{\'a}gyi, {I. M.} and C. V{\'a}rhelyi and D. Hunyadi and Nagy, {R. I.} and Tihi, {N. G.} and F. Goga and J. Papp and R. Szalay and G. Pokol",
year = "2016",
month = "6",
day = "18",
doi = "10.1007/s10973-016-5591-7",
language = "English",
pages = "1--9",
journal = "Journal of Thermal Analysis and Calorimetry",
issn = "1388-6150",
publisher = "Springer Netherlands",

}

TY - JOUR

T1 - Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

AU - Barta Holló, B.

AU - Szilágyi, I. M.

AU - Várhelyi, C.

AU - Hunyadi, D.

AU - Nagy, R. I.

AU - Tihi, N. G.

AU - Goga, F.

AU - Papp, J.

AU - Szalay, R.

AU - Pokol, G.

PY - 2016/6/18

Y1 - 2016/6/18

N2 - Three complexes of general formula PtCl2R2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an)2Cl2] (1), [Pt(pa)2Cl2] (2) and [Pt(aph)2Cl2] (3), where an = 2-aminonaphthalene, pa = 2-aminopyrimidine, aph = 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI–MS and NMR), and tested against selected Gram(+) and Gram(–) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria.

AB - Three complexes of general formula PtCl2R2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an)2Cl2] (1), [Pt(pa)2Cl2] (2) and [Pt(aph)2Cl2] (3), where an = 2-aminonaphthalene, pa = 2-aminopyrimidine, aph = 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI–MS and NMR), and tested against selected Gram(+) and Gram(–) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria.

KW - Amine ligand

KW - Antimicrobial activity

KW - Pt(II) complexes

KW - Spectroscopic data

KW - Thermal properties

UR - http://www.scopus.com/inward/record.url?scp=84975106336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975106336&partnerID=8YFLogxK

U2 - 10.1007/s10973-016-5591-7

DO - 10.1007/s10973-016-5591-7

M3 - Article

SP - 1

EP - 9

JO - Journal of Thermal Analysis and Calorimetry

JF - Journal of Thermal Analysis and Calorimetry

SN - 1388-6150

ER -