Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

B. Barta Holló, I. M. Szilágyi, Cs Várhelyi, D. Hunyadi, R. I. Nagy, N. G. Tihi, F. Goga, J. Papp, R. Szalay, G. Pokol

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Three complexes of general formula PtCl2R2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an)2Cl2] (1), [Pt(pa)2Cl2] (2) and [Pt(aph)2Cl2] (3), where an = 2-aminonaphthalene, pa = 2-aminopyrimidine, aph = 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI–MS and NMR), and tested against selected Gram(+) and Gram(–) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria.

Original languageEnglish
Pages (from-to)1733-1741
Number of pages9
JournalJournal of Thermal Analysis and Calorimetry
Volume127
Issue number2
DOIs
Publication statusPublished - Feb 1 2017

Keywords

  • Amine ligand
  • Antimicrobial activity
  • Pt(II) complexes
  • Spectroscopic data
  • Thermal properties

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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  • Cite this

    Barta Holló, B., Szilágyi, I. M., Várhelyi, C., Hunyadi, D., Nagy, R. I., Tihi, N. G., Goga, F., Papp, J., Szalay, R., & Pokol, G. (2017). Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands. Journal of Thermal Analysis and Calorimetry, 127(2), 1733-1741. https://doi.org/10.1007/s10973-016-5591-7