Synthesis of Vinca Alkaloids and Related Compounds, XXXIV Synthesis of (3S, 14S, 16S)‐Bromovincamines and Bromoapovincamines by Regioselective Bromination

Lajos Szabó, László Dobay, György Kalaus, E. Gács-Baitz, József Tamás, Csaba Szántay

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

By bromination of the iminium salt 2a (X‐Cl), the 9‐bromo derivative 2c (X=ClO4) is obtained in isomerfree state. Bromination of the lactam 8d leads to a ca. 7.5:1 mixture of 11‐bromo 8c and 9‐bromo 8a lactams. These precursors have been used to synthesize 9‐, 10‐ and 11‐bromovincamines 11a‐c, and 9‐, 10‐ and 11‐bromoapovincamines 12a‐c.

Original languageEnglish
Pages (from-to)781-789
Number of pages9
JournalArchiv der Pharmazie
Volume320
Issue number9
DOIs
Publication statusPublished - 1987

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Vinca Alkaloids
Lactams
Halogenation
Salts
perchlorate

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

Cite this

Synthesis of Vinca Alkaloids and Related Compounds, XXXIV Synthesis of (3S, 14S, 16S)‐Bromovincamines and Bromoapovincamines by Regioselective Bromination. / Szabó, Lajos; Dobay, László; Kalaus, György; Gács-Baitz, E.; Tamás, József; Szántay, Csaba.

In: Archiv der Pharmazie, Vol. 320, No. 9, 1987, p. 781-789.

Research output: Contribution to journalArticle

Szabó, Lajos ; Dobay, László ; Kalaus, György ; Gács-Baitz, E. ; Tamás, József ; Szántay, Csaba. / Synthesis of Vinca Alkaloids and Related Compounds, XXXIV Synthesis of (3S, 14S, 16S)‐Bromovincamines and Bromoapovincamines by Regioselective Bromination. In: Archiv der Pharmazie. 1987 ; Vol. 320, No. 9. pp. 781-789.
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