Synthesis of Vinca Alkaloids and Related Compounds, XXXIV Synthesis of (3S, 14S, 16S)‐Bromovincamines and Bromoapovincamines by Regioselective Bromination

Lajos Szabó, László Dobay, György Kalaus, Eszter Gács‐Baitz, József Tamás, Csaba Szántay

Research output: Contribution to journalArticle

9 Citations (Scopus)


By bromination of the iminium salt 2a (X‐Cl), the 9‐bromo derivative 2c (X=ClO4) is obtained in isomerfree state. Bromination of the lactam 8d leads to a ca. 7.5:1 mixture of 11‐bromo 8c and 9‐bromo 8a lactams. These precursors have been used to synthesize 9‐, 10‐ and 11‐bromovincamines 11a‐c, and 9‐, 10‐ and 11‐bromoapovincamines 12a‐c.

Original languageEnglish
Pages (from-to)781-789
Number of pages9
JournalArchiv der Pharmazie
Issue number9
Publication statusPublished - 1987


ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

Cite this