Synthesis of vinca alkaloids and related compounds-XVI. New route to the stereoselective synthesis of (+)-vincamine, (-)-vincamone and (+)-apovincaminic acid esters

Lajos Szabó, János Sápi, György Kalaus, G. Argay, A. Kálmán, E. Gács-Baitz, József Tamás, Csaba Szántay

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Abstract

A stereoselective method has been elaborated for the synthesis of oxime esters, (-)-4a, b, from which, as common intermediates, (+)-apovincaminic acid esters (3a,b), (+)-vincamine (1) and (-)-vincamone (2) can be prepared.

Original languageEnglish
Pages (from-to)3737-3747
Number of pages11
JournalTetrahedron
Volume39
Issue number22
DOIs
Publication statusPublished - 1983

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Vincamine
Vinca Alkaloids
Esters
Oximes
apovincaminic acid

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of vinca alkaloids and related compounds-XVI. New route to the stereoselective synthesis of (+)-vincamine, (-)-vincamone and (+)-apovincaminic acid esters. / Szabó, Lajos; Sápi, János; Kalaus, György; Argay, G.; Kálmán, A.; Gács-Baitz, E.; Tamás, József; Szántay, Csaba.

In: Tetrahedron, Vol. 39, No. 22, 1983, p. 3737-3747.

Research output: Contribution to journalArticle

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AU - Sápi, János

AU - Kalaus, György

AU - Argay, G.

AU - Kálmán, A.

AU - Gács-Baitz, E.

AU - Tamás, József

AU - Szántay, Csaba

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