Synthesis of vinca alkaloids and related compounds, Part XCVI Nitration study of vinblastine-type bisindole alkaloids

Lajos Szab, Hedvig Blcskei, Baitz Gcs Eszter, Marianna Mk, Csaba Szntay

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested (10-5-10-9M). 5b also showed potency in the screen for colon cancer and leukemia.

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalArchiv der Pharmazie
Volume334
Issue number12
DOIs
Publication statusPublished - Dec 1 2001

Keywords

  • Antitumor activity
  • Nitration of bisindole alkaloids
  • Reduction

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

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