Antiproliferatív hatású tiofén és α-tertiofénszármazékok eloállítá sa

Translated title of the contribution: Synthesis of thiophene and α-terthiophene derivatives with antiproliferative activity

Zsolt Székelyhidi, János Pató, Bálint Hegymegi-Barakonyi, Péter Bánhegyi, György Mészáros, G. Kéri, L. Őrfi

Research output: Contribution to journalArticle

Abstract

We have synthesised a series of known α-terthiophene lead molecules with PKC (protein kinase C) inhibitory activity and the compounds were tested in cell proliferation assay on EGF-RTK (epidermal growth factor receptor protein tyrosine kinase) overexpressing tumour cell line (A431). We found that two of them had excellent antiproliferative activity. We prepared a focused molecule library around the thiophene and the terthiophene scaffold and examined these compounds in cell proliferation assay on A431.

Original languageHungarian
Pages (from-to)185-193
Number of pages9
JournalActa Pharmaceutica Hungarica
Volume75
Issue number4
Publication statusPublished - 2005

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Thiophenes
Cell Proliferation
Tumor Cell Line
Epidermal Growth Factor Receptor
Protein Kinase C
Libraries
alpha-terthienyl

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Székelyhidi, Z., Pató, J., Hegymegi-Barakonyi, B., Bánhegyi, P., Mészáros, G., Kéri, G., & Őrfi, L. (2005). Antiproliferatív hatású tiofén és α-tertiofénszármazékok eloállítá sa. Acta Pharmaceutica Hungarica, 75(4), 185-193.

Antiproliferatív hatású tiofén és α-tertiofénszármazékok eloállítá sa. / Székelyhidi, Zsolt; Pató, János; Hegymegi-Barakonyi, Bálint; Bánhegyi, Péter; Mészáros, György; Kéri, G.; Őrfi, L.

In: Acta Pharmaceutica Hungarica, Vol. 75, No. 4, 2005, p. 185-193.

Research output: Contribution to journalArticle

Székelyhidi, Z, Pató, J, Hegymegi-Barakonyi, B, Bánhegyi, P, Mészáros, G, Kéri, G & Őrfi, L 2005, 'Antiproliferatív hatású tiofén és α-tertiofénszármazékok eloállítá sa', Acta Pharmaceutica Hungarica, vol. 75, no. 4, pp. 185-193.
Székelyhidi Z, Pató J, Hegymegi-Barakonyi B, Bánhegyi P, Mészáros G, Kéri G et al. Antiproliferatív hatású tiofén és α-tertiofénszármazékok eloállítá sa. Acta Pharmaceutica Hungarica. 2005;75(4):185-193.
Székelyhidi, Zsolt ; Pató, János ; Hegymegi-Barakonyi, Bálint ; Bánhegyi, Péter ; Mészáros, György ; Kéri, G. ; Őrfi, L. / Antiproliferatív hatású tiofén és α-tertiofénszármazékok eloállítá sa. In: Acta Pharmaceutica Hungarica. 2005 ; Vol. 75, No. 4. pp. 185-193.
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