Synthesis of the repeating unit of the O-specific polysaccharide of Shigella sonnei and quantitation of its serologic activity

Anikó Tóth, Adél Medgyes, István Bajza, András Lipták, Gyula Batta, Tivadar Kontrohr, Klára Péterffy, Vince Pozsgay

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Abstract

The chemical synthesis of the zwitterionic disaccharide 2 is described that corresponds to the repeating unit of the O-specific polysaccharide (1) of the Gram-negative human pathogen Shigella sonnei. Passive hemolysis inhibition tests using a hyperimmune rabbit serum raised against S. sonnei showed that the serologic activity of the disaccharide 2 is nearly 2- and 3- fold higher than those of its component monosaccharides. NMR data of 2 are in support of the proposed structure of the O-specific polysaccharide.

Original languageEnglish
Pages (from-to)19-21
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 3 2000

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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