TeroButil-ciklopentännal kondenzalt pirimidin-4-onok1

Translated title of the contribution: Synthesis of terf-butylcyclopentane-fused pyrimidin-4-ones

Research output: Contribution to journalArticle

Abstract

In the reactions of ethyl (1R*,2S*,AS*)-2amino-4-tert-butyl-l-cyclopentanecarboxylate (4) orc ethyl (1R*,2S*,4S*)-2-amino-4-tert-butyI-l- cyclopentanecarboxamide (6) or (1R*,3S*,5S*)-3tert-butyl-6-aza-bicyclo[3.2.0]heptan-7-one (2) with imidates or triethyl orthobenzoate, tertbutylcyclopentane-fused dihydropyrimidin-4-ones (7a-e) were prepared. The azetidinone 2 with lactim ethers furnished pyrrolo-, pyrido- and azepino[l,2-o]pyrimidin-4-ones (8-10) in ringenlargement reactions. The ethyl (IR*,2S*,4S )-2amino-4-tert-buryl-l-cyclopentanecarboxylate (4) and ethyl (lR*,2S*,4S*)-2-benzylamino-4-tert-butyl-l- cyclopentanecarboxylate (5) and potassium cyanate or- phenyl isocyanate or potassium thiocyanate or phenyl isothiocyanate, yielded pyrimidine-2,4-diones or 2-thioxopyrimidin-4-ones (11-22).

Original languageHungarian
Pages (from-to)17-24
Number of pages8
JournalMagyar Kemiai Folyoirat, Kemiai Kozlemenyek
Volume104
Issue number1
Publication statusPublished - 1998

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Imidoesters
Ethers
potassium thiocyanate
phenyl isocyanate
2-azetidinone
phenylisothiocyanate
pyrimidine
potassium cyanate

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

TeroButil-ciklopentännal kondenzalt pirimidin-4-onok1. / Szakonyi, Z.; Fülöp, F.; Bernáth, G.

In: Magyar Kemiai Folyoirat, Kemiai Kozlemenyek, Vol. 104, No. 1, 1998, p. 17-24.

Research output: Contribution to journalArticle

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AU - Bernáth, G.

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