Synthesis of sulfonic acid analogues of the non-reducing end trisaccharide of the antithrombin binding domain of heparin

László Lázár, Mihály Herczeg, Anikó Fekete, A. Borbás, A. Lipták, S. Antus

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Three sulfonic acid trisaccharides related to the antithrombin-binding DEFGH domain of heparin were synthesised. Trisaccharides carrying the sulfonatomethyl moiety at position 2 or 6 were prepared in high yields by [DE+F] couplings using the same disaccharide uronate donor and the appropriate sulfonic acid acceptor, respectively. The trisaccharide with a 3-deoxy-3-sulfonatomethyl function could be obtained with high efficacy by a [D+EF] coupling where the carboxylic function of the EF uronate acceptor was created at a disaccharide level.

Original languageEnglish
Pages (from-to)6711-6714
Number of pages4
JournalTetrahedron Letters
Volume51
Issue number51
DOIs
Publication statusPublished - Dec 22 2010

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Trisaccharides
Sulfonic Acids
Antithrombins
Heparin
Disaccharides

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of sulfonic acid analogues of the non-reducing end trisaccharide of the antithrombin binding domain of heparin. / Lázár, László; Herczeg, Mihály; Fekete, Anikó; Borbás, A.; Lipták, A.; Antus, S.

In: Tetrahedron Letters, Vol. 51, No. 51, 22.12.2010, p. 6711-6714.

Research output: Contribution to journalArticle

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AU - Herczeg, Mihály

AU - Fekete, Anikó

AU - Borbás, A.

AU - Lipták, A.

AU - Antus, S.

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