Synthesis of some novel 2-phenylpyridazino[4,5-b][1,5]thiazepines

P. Mátyus, Erzsébet Zára-Kaczián, Sándor Boros, Zsolt Böcskei

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Synthesis of some derivatives of the pyridazino[4,5-b][1,5]thiazepine ring system is reported. Thus, 5-benzyl-8-methyl-2-phenyl-2,3,4,5-tetrahydro-5H-pyridazino[4,5-b][1,5] thiazepin-9(8H)-one (5) was prepared by an intramolecular S-alkylation reaction, whereas the thiazepine ring of sulfone analogue 21, and that of the novel tricyclic pyrrolidino fused ring system 22 was elaborated by an intramolecular C-alkylation reaction. Unexpected formation of bicyclic pyrido- and thiazine fused pyridazine systems are also discussed.

Original languageEnglish
Pages (from-to)583-590
Number of pages8
JournalJournal of Heterocyclic Chemistry
Volume33
Issue number3
Publication statusPublished - May 1996

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Thiazepines
Alkylation
Thiazines
Sulfones
Derivatives

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Mátyus, P., Zára-Kaczián, E., Boros, S., & Böcskei, Z. (1996). Synthesis of some novel 2-phenylpyridazino[4,5-b][1,5]thiazepines. Journal of Heterocyclic Chemistry, 33(3), 583-590.

Synthesis of some novel 2-phenylpyridazino[4,5-b][1,5]thiazepines. / Mátyus, P.; Zára-Kaczián, Erzsébet; Boros, Sándor; Böcskei, Zsolt.

In: Journal of Heterocyclic Chemistry, Vol. 33, No. 3, 05.1996, p. 583-590.

Research output: Contribution to journalArticle

Mátyus, P, Zára-Kaczián, E, Boros, S & Böcskei, Z 1996, 'Synthesis of some novel 2-phenylpyridazino[4,5-b][1,5]thiazepines', Journal of Heterocyclic Chemistry, vol. 33, no. 3, pp. 583-590.
Mátyus, P. ; Zára-Kaczián, Erzsébet ; Boros, Sándor ; Böcskei, Zsolt. / Synthesis of some novel 2-phenylpyridazino[4,5-b][1,5]thiazepines. In: Journal of Heterocyclic Chemistry. 1996 ; Vol. 33, No. 3. pp. 583-590.
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