Synthesis of Segments of the GnRH‐Associated Peptide

C. Somlai, Wolfgang König, Jochen Knolle

Research output: Contribution to journalArticle

Abstract

The 56 amino acid containing GnRH‐associated peptide (GAP) may be prepared by a combination of fragment condensation and solid‐phase peptide synthesis (SPPS). The solution‐phase synthesis of the fragments 1–9 is described. Furthermore, we report on the selective cleavage of benzyl esters by catalytic hydrogenation in the presence of the 9‐fluorenylmethyloxycarbonyl (Fmoc) protecting group. The C‐terminal 15 amino acid containing fragment of GAP (10) was synthesized by SPPS.

Original languageEnglish
Pages (from-to)1055-1061
Number of pages7
JournalLiebigs Annalen der Chemie
Volume1992
Issue number10
DOIs
Publication statusPublished - 1992

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Peptides
Amino Acids
Peptide Fragments
Hydrogenation
Esters

Keywords

  • Gonadoliberin‐releasing hormone
  • Peptides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Synthesis of Segments of the GnRH‐Associated Peptide. / Somlai, C.; König, Wolfgang; Knolle, Jochen.

In: Liebigs Annalen der Chemie, Vol. 1992, No. 10, 1992, p. 1055-1061.

Research output: Contribution to journalArticle

Somlai, C. ; König, Wolfgang ; Knolle, Jochen. / Synthesis of Segments of the GnRH‐Associated Peptide. In: Liebigs Annalen der Chemie. 1992 ; Vol. 1992, No. 10. pp. 1055-1061.
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