Abstract
The 56 amino acid containing GnRH‐associated peptide (GAP) may be prepared by a combination of fragment condensation and solid‐phase peptide synthesis (SPPS). The solution‐phase synthesis of the fragments 1–9 is described. Furthermore, we report on the selective cleavage of benzyl esters by catalytic hydrogenation in the presence of the 9‐fluorenylmethyloxycarbonyl (Fmoc) protecting group. The C‐terminal 15 amino acid containing fragment of GAP (10) was synthesized by SPPS.
| Original language | English |
|---|---|
| Pages (from-to) | 1055-1061 |
| Number of pages | 7 |
| Journal | Liebigs Annalen der Chemie |
| Volume | 1992 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1992 |
Keywords
- Gonadoliberin‐releasing hormone
- Peptides
ASJC Scopus subject areas
- Medicine(all)
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Somlai, C., König, W., & Knolle, J. (1992). Synthesis of Segments of the GnRH‐Associated Peptide. Liebigs Annalen der Chemie, 1992(10), 1055-1061. https://doi.org/10.1002/jlac.1992199201174