Abstract
The 56 amino acid containing GnRH‐associated peptide (GAP) may be prepared by a combination of fragment condensation and solid‐phase peptide synthesis (SPPS). The solution‐phase synthesis of the fragments 1–9 is described. Furthermore, we report on the selective cleavage of benzyl esters by catalytic hydrogenation in the presence of the 9‐fluorenylmethyloxycarbonyl (Fmoc) protecting group. The C‐terminal 15 amino acid containing fragment of GAP (10) was synthesized by SPPS.
| Original language | English |
|---|---|
| Pages (from-to) | 1055-1061 |
| Number of pages | 7 |
| Journal | Liebigs Annalen der Chemie |
| Volume | 1992 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1992 |
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Keywords
- Gonadoliberin‐releasing hormone
- Peptides
ASJC Scopus subject areas
- Medicine(all)
Cite this
Synthesis of Segments of the GnRH‐Associated Peptide. / Somlai, C.; König, Wolfgang; Knolle, Jochen.
In: Liebigs Annalen der Chemie, Vol. 1992, No. 10, 1992, p. 1055-1061.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of Segments of the GnRH‐Associated Peptide
AU - Somlai, C.
AU - König, Wolfgang
AU - Knolle, Jochen
PY - 1992
Y1 - 1992
N2 - The 56 amino acid containing GnRH‐associated peptide (GAP) may be prepared by a combination of fragment condensation and solid‐phase peptide synthesis (SPPS). The solution‐phase synthesis of the fragments 1–9 is described. Furthermore, we report on the selective cleavage of benzyl esters by catalytic hydrogenation in the presence of the 9‐fluorenylmethyloxycarbonyl (Fmoc) protecting group. The C‐terminal 15 amino acid containing fragment of GAP (10) was synthesized by SPPS.
AB - The 56 amino acid containing GnRH‐associated peptide (GAP) may be prepared by a combination of fragment condensation and solid‐phase peptide synthesis (SPPS). The solution‐phase synthesis of the fragments 1–9 is described. Furthermore, we report on the selective cleavage of benzyl esters by catalytic hydrogenation in the presence of the 9‐fluorenylmethyloxycarbonyl (Fmoc) protecting group. The C‐terminal 15 amino acid containing fragment of GAP (10) was synthesized by SPPS.
KW - Gonadoliberin‐releasing hormone
KW - Peptides
UR - http://www.scopus.com/inward/record.url?scp=84986648587&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84986648587&partnerID=8YFLogxK
U2 - 10.1002/jlac.1992199201174
DO - 10.1002/jlac.1992199201174
M3 - Article
AN - SCOPUS:84986648587
VL - 1992
SP - 1055
EP - 1061
JO - LIEBIGS ANN. CHEM.
JF - LIEBIGS ANN. CHEM.
SN - 1434-193X
IS - 10
ER -