Synthesis of quinazolino‐1,3‐benzothiazine derivatives

János Szabó, Ernest Bani‐Akoto, G. Dombi, G. Bernáth, L. Fodor, P. Sohár

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Abstract

The ring‐closure reactions of N‐(3,4‐dimethoxyphenylthiomethyl)‐2‐nitrobenzamide derivatives 5a,b with phosphoryl chloride gave 4‐(2‐nitrophenyl)‐2H1,3‐benzothiazine derivatives 7a,b, which on reduction yielded 4‐(2′‐aminophenyl)‐3,4‐dihydro‐2H‐1,3‐benzothiazines 8a,b. Reaction of these compounds with phosgene led to a new heterocyclic ring system, 6H,8H‐quinazolino[3,4‐c][1,3]benzothiazine derivatives 9a,b. The structures of the title compounds were proved via their ir and nmr (1H, 13C) spectra.

Original languageEnglish
Pages (from-to)1513-1517
Number of pages5
JournalJournal of Heterocyclic Chemistry
Volume29
Issue number6
DOIs
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Organic Chemistry

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