Synthesis of quinazolino-1,3-benzothiazine derivatives

J. Szabo, E. Bani-Akoto, Gy Dombi, G. Bernath, L. Fodor, P. Sohar

Research output: Contribution to journalArticle

Abstract

The ring-closure reactions of N-(3,4-dimethoxyphenylthiomethyl)-2-nitrobenzamide derivatives 5a,b with phosphoryl chloride gave 4-(2'-nitrophenyl)-2H-1,3-benzothiazine derivatives 7a,b, which on reduction yielded 4-(2'-aminophenyl)-3,4-dihydro-2H-1,3-benzothiazines 8a,b. Reaction of these compounds with phosgene led to the derivatives 9a,b of a new heterocyclic ring system, 6H,8H-quinazolino[3,4-c] [1,3]benzothiazine. The structures of the title compounds were proved by their ir and nmr (1H, 13C) spectra.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalActa pharmaceutica Hungarica
Volume64
Issue number5
Publication statusPublished - Jan 1 1994

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ASJC Scopus subject areas

  • Pharmaceutical Science

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