Synthesis of quinazolino-1,3-benzothiazine derivatives

János Szabó, Ernest Bani-Akoto, G. Dombi, G. Bernáth, L. Fodor, P. Sohár

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Abstract

The ring-closure reactions of N-(3,4-dimethoxyphenylthiomethyl)-2-nitrobenzamide derivatives 5a,b with phosphoryl chloride gave 4-(2-nitrophenyl)-2H-1,3-benzothiazine derivatives 7a,b, which on reduction yielded 4-(2'-aminophenyl)-3,4-dihydro-2H-1,3-benzothiazines 8a,b. Reaction of these compounds with phosgene led to a new heterocyclic ring system, 6-H,8H-quinazolino[3,4-c][1,3]benzothiazine derivatives 9a,b. The structures of the title compounds were proved via their ir and nmr (1H, 13C) spectra.

Original languageEnglish
Pages (from-to)1513-1517
Number of pages5
JournalMathematical Problems in Engineering
Volume29
Issue number6
Publication statusPublished - Oct 1 1992

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Synthesis
Derivatives
Derivative
Ring
Closure

ASJC Scopus subject areas

  • Mathematics(all)
  • Engineering(all)

Cite this

Synthesis of quinazolino-1,3-benzothiazine derivatives. / Szabó, János; Bani-Akoto, Ernest; Dombi, G.; Bernáth, G.; Fodor, L.; Sohár, P.

In: Mathematical Problems in Engineering, Vol. 29, No. 6, 01.10.1992, p. 1513-1517.

Research output: Contribution to journalArticle

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