Synthesis of pyrimido[2,1-b]thiazin-6-one by retro Diels-Alder reaction

Ferenc Fülöp, Imre Huber, Ágnes Szabó, Gábor Bernáth, Pál Sohár

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17 Citations (Scopus)

Abstract

The first mild retrodiene processes resulting in bicyclic heterocycles are described. From norbornene diexo- and diendo-β-amino acids with chloroalkyl isothiocyanates, compounds 3-6 were prepared, which, by retrodiene decomposition, furnished 7 and 8.

Original languageEnglish
Pages (from-to)7673-7676
Number of pages4
JournalTetrahedron
Volume47
Issue number36
DOIs
Publication statusPublished - Sep 2 1991

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Keywords

  • pyrimido[2,1-b]thiazin-6-one.
  • retrodiene decomposition
  • thiazino[2,3-b]quinazolin-6-one
  • thiazolo[2,3-b]quinazolin-5-one
  • thiazolo[3,2-a]pyrimidin-5-one

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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