Synthesis of pure methyl [(2S,3R,αR)-1-(3-bromo-4-methoxyphenyl)-3-(α-acetoxy)ethyl-4- oxoazetidin-2-carboxylate] and its enantiomer

Zsuzsanna Sánta, László Párkányi, Ildikó Németh, József Nagy, József Nyitrai

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7 Citations (Scopus)


Synthesis of key intermediates leading to 2-iso-oxacephems was carried out starting from L- and D-threonine. As predicted in our previous paper (Tetrahedron Lett. 1995, 36, 8303-8306) all diastereomers of 2-iso-oxacephems can be prepared from the appropriate enantiomers of the amino acid threonine. The absolute configuration of the 2,3- and α-carbon atoms in the β-lactam structure was determined by X-ray crystallographic studies.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalTetrahedron Asymmetry
Issue number1
Publication statusPublished - Feb 5 2001

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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