POTENCIALIS CCK-ANTAGONISTA KINAZOLON-SZARMAZEKOK SZINTEZISE II

Translated title of the contribution: Synthesis of potential CCK antagonist quinazolone derivatives

M. Szabo, J. Kokosi, A. Kovacs, L. Orfi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An alternative route has been developed for the synthesis of [1,4]diazepino[3,4-b]quinazolones (2), a new ring system of heterocondensed quinazolones. 2,3-Bifunctional (4) were synthesized by halogenation of 2-alkyl-quinazolone-3-propionic acids, yield from the reaction of 2-alkyl-benzoxazone (3) with β-alanine. The reaction of haloalkyl compounds (5, 6) with N-nucleophiles produces [1,4]oxazepino-[3,4-b]quinazolones (8), a new heterocyclic ring system, and 3-[2'-hydroxy-ethyl-, or 3-[2'-chloro-ethyl-4'oxo(3'H)-quinazoline-3'-yl]-propionamides (7, 9) in consecutive reaction. The cyclisation of 2-aminoalkyl-3-propionates (13) resulted in the title compounds (14). Physical data and properties of the newly synthesized compounds such as IR, UV and NMR spectra were obtained for all compounds reported.

Original languageHungarian
Pages (from-to)175-181
Number of pages7
JournalActa pharmaceutica Hungarica
Volume65
Issue number5
Publication statusPublished - Jan 1 1995

    Fingerprint

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this