POTENCIALIS CCK-ANTAGONISTA KINAZOLON-SZARMAZEKOK SZINTEZISE

Translated title of the contribution: Synthesis of potential CCK antagonist quinazolone derivative

M. Szabo, J. Kokosi, L. Orfi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An original route has been found for the synthesis of [1,4]diazepino-quinazolones, a new ring system of heterocondensed quinazolones. These anthranilicacid-alanin-β-alanin cyclopeptide derivatives constitute a structural moiety of asperlicin, the first natural cholecystokinin antagonist alkaloid. These compounds are therefore potential CCK antagonists. The new compounds were prepared via condensation of 2-amino-alkyl-quinazolones, obtained from 2-alkyl-quinazolones by side-chain substitution, with 1,3-bifunctional-reagents. We studied the cyclisation process under basic, acidic and phase-transfer catalyzed conditions. The structures of the synthesized compounds were characterized by IR, UV and NMR spectroscopy.

Original languageHungarian
Pages (from-to)133-138
Number of pages6
JournalActa pharmaceutica Hungarica
Volume65
Issue number4
Publication statusPublished - Jan 1 1995

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ASJC Scopus subject areas

  • Pharmaceutical Science

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