POTENCIALIS CCK-ANTAGONISTA KINAZOLON-SZARMAZEKOK SZINTEZISE

Translated title of the contribution: Synthesis of potential CCK antagonist quinazolone derivative

M. Szabo, J. Kokosi, L. Orfi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An original route has been found for the synthesis of [1,4]diazepino-quinazolones, a new ring system of heterocondensed quinazolones. These anthranilicacid-alanin-β-alanin cyclopeptide derivatives constitute a structural moiety of asperlicin, the first natural cholecystokinin antagonist alkaloid. These compounds are therefore potential CCK antagonists. The new compounds were prepared via condensation of 2-amino-alkyl-quinazolones, obtained from 2-alkyl-quinazolones by side-chain substitution, with 1,3-bifunctional-reagents. We studied the cyclisation process under basic, acidic and phase-transfer catalyzed conditions. The structures of the synthesized compounds were characterized by IR, UV and NMR spectroscopy.

Translated title of the contributionSynthesis of potential CCK antagonist quinazolone derivative
Original languageHungarian
Pages (from-to)133-138
Number of pages6
JournalActa pharmaceutica Hungarica
Volume65
Issue number4
Publication statusPublished - Jan 1 1995

ASJC Scopus subject areas

  • Pharmaceutical Science

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