Synthesis of Polyfused Heteroaromatics by Palladium-Catalyzed Cross-Coupling Reaction

Géza Timári, György Hajós, Zsuzsanna Riedl, Mariann Béres, Tibor Soós, András Messmer, Salo Gronowitz

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3 Citations (Scopus)


The palladium-catalyzed coupling of unsaturated halides or triflates with organostannanes (the Stille reaction) or with organo-boronic acids (the Suzuki reaction) has envolved as a powerful means of carbon-carbon bond formation. As an extention of our work on the synthesis and reactivity of positively charged bridge-head nitrogen containing fused azinium salts, we have been studying the formation of polyfused heteroaromatics with angular anellation pattern. The reaction of such positively charged salts with nucleophiles has proven to be a suitable tool for the preparation of heteroaryl dienes, which have been shown to be excellent intermediates for several ring closure reaction. A selection of results will be presented, including applications to natural product synthesis.

Original languageEnglish
Pages (from-to)236-241
Number of pages6
Issue number10
Publication statusPublished - Feb 1992



  • azinium salt
  • cross-coupling reaction
  • furoquinolone
  • review
  • thienoisoquinoline

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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