Synthesis of phosphoramide mustard analogues of daunomycin and carminomycin

Andrea Csorvási, K. Kövér, Márta M. Menyhárt, F. Sztaricskai, Yaroslav V. Dobrynin, Tamara G. Nikolaeva

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

New phosphoramide mustards (6-8) have been prepared from the antibiotics 2 and 3, and from 5. The mixture of cyclophosphamides could be separated by preparative layer and column chromatography. The assignments of configuration to the isomeric phosphoramidates was based on the magnetic anisotrophy of the P=O bond. The synthesized compounds 6a,b-8a,b (mixture of isomers) were tested for inhibitory activity on the [3H]-thymidine incorporation into the DNA of tumor cells, using ovarian carcinoma cell line.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalArchiv der Pharmazie
Volume331
Issue number9
DOIs
Publication statusPublished - Sep 1998

Fingerprint

Phosphoramide Mustards
Carubicin
Daunorubicin
Cyclophosphamide
Thymidine
Chromatography
Cells
Anti-Bacterial Agents
Carcinoma
Cell Line
Column chromatography
DNA
Isomers
Tumors
Neoplasms
phosphoramide mustard
phosphoramidic acid

Keywords

  • Antitumor activity
  • Carminomycin
  • Daunomycin
  • Magnetic anisotropy of the P=O bond
  • Phosphoramide mustards

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Synthesis of phosphoramide mustard analogues of daunomycin and carminomycin. / Csorvási, Andrea; Kövér, K.; Menyhárt, Márta M.; Sztaricskai, F.; Dobrynin, Yaroslav V.; Nikolaeva, Tamara G.

In: Archiv der Pharmazie, Vol. 331, No. 9, 09.1998, p. 265-268.

Research output: Contribution to journalArticle

Csorvási, Andrea ; Kövér, K. ; Menyhárt, Márta M. ; Sztaricskai, F. ; Dobrynin, Yaroslav V. ; Nikolaeva, Tamara G. / Synthesis of phosphoramide mustard analogues of daunomycin and carminomycin. In: Archiv der Pharmazie. 1998 ; Vol. 331, No. 9. pp. 265-268.
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