Synthesis of phosphonates in a continuous flow manner

Nóra Tóth, Ádám Tajti, Katalin Ladányi-Pára, Erika Bálint, G. Keglevich

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The synthesis of dialkyl H-phosphonates and α-aminophosphonates was studied in a continuous flow microwave reactor. Depending on the conditions, the alcoholysis of dialkyl H-phosphonates could be fine-tuned towards the mixed and the fully transesterified products. The continuous flow synthesis of α-aryl-α-aminophosphonates was elaborated utilizing the aza-Pudovik reaction of imines and dialkyl H-phosphonates, as well as the by the Kabachnik-Fields condensation of primary amines, benzaldehyde and > P(O)H reagents.

Original languageEnglish
JournalPhosphorus, Sulfur and Silicon and the Related Elements
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • alcoholysis
  • continuous flow reactor
  • Dialkyl H-phosphonates
  • Kabachnik-Fields reaction
  • Pudovik reaction
  • α-aminophosphonates

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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