Synthesis of pH-sensitive copolymer thin solid films embedded with silver nanoparticles for controlled release and their fungicide properties

L. Janovák, S. P. Tallósy, M. Sztakó, Deák, T. Bitó, N. Buzás, G. Bártfai, I. Dékány

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Poly(methacrylic acid-co-butyl methacrylate) copolymer was synthesized which showed more than tenfold swelling above the pH of 4.5 within a narrow (0.5) pH range with the monomer composition of 85 mol% MAA and 15 mol% BMA. The water uptake properties of the prepared copolymers were adjustable by the monomer composition. Thin films were prepared consisting of a lower layer of silver nanoparticles (∼ 0.033 mg/cm2) and an upper layer of pH-sensitiv e polymer {∼ 2.0mg/cm2). The AgNPs (d = ∼20nm) content of the laxers was 1.64 wt%. Below pH 4.5, 17 % of the active agent content was released after 1 h. however, at higher pH values (> 4.5) 100 % of the AgNPs left the thin layer. The antifungal effect was successful against Candida albicans, because the treatment with 10ppm AgNPs dispersion killed 100 % of initial (∼ 2.85 × 103 cfu/mL) yeast after 30 min. The minimal effective concentration of AgNPs is ∼ 28500 cfu Candida albicanslmg AgNP for a contact time of 30 min.

Original languageEnglish
Pages (from-to)628-636
Number of pages9
JournalJournal of Drug Delivery Science and Technology
Volume24
Issue number6
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • Acrylate copolymer thin film
  • Fungicidal effect
  • Ph sensitivity
  • Silver nanoparticles
  • Silver release

ASJC Scopus subject areas

  • Pharmaceutical Science

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